Weekly Dosing of an Integrative Chemotherapy Combination to Treat Advanced Pancreatic Cancer

OBJECTIVES: * The primary objective is to determine the effectiveness the chemotherapy combination in improving the experience of those with advanced pancreatic cancer in * Pain control and other aspects of quality of life * Reduction of the tumor size or stabilization of tumor growth * Progression free survival * Overall survival * The secondary objective is to determine the safety of this chemotherapy combination by monitoring and the managing the potential side effects DOSE REGIMEN OUTLINE: Paclitaxel 60mg/m2 IV weekly; Oxaliplatin 50mg/m2 IV weekly; Leucovorin 20 mg/m2 IV weekly, minimum of 40 mg; 5FU 425mg/m2 IV weekly; Weekly for 12 weeks; Calcium and magnesium 1gram each IV prior to and after Oxaliplatin therapy; Glutathione 1500mg/m2 prior to Oxaliplatin DURATION OF STUDY PERIOD: Patient will continue study treatment until death, disease progression, unacceptable toxicity, patient refusal, or treatment delay greater than 3 weeks, 12 weeks initially, can than continue at discretion of investigator. EXPECTED NUMBER OF PATIENTS: A total of 80 patients (40 second line of treatment and 40 third line or greater of treatment) will be enrolled for this study beginning in May 2006. QUALITY OF LIFE: Quality of life will be assessed at baseline, each month of treatment and at the end of study therapy.