Safety and Immunogenicity of IMVAMUNE® (MVA-BN®) Smallpox Vaccine in HIV Infected Patients

Exclusion Criteria

• •Impairment of immunologic function (other than HIV infection).
• •History of coronary heart disease, myocardial infarction, angina, congestive heart failure, cardiomyopathy, stroke or transient ischemic attack, uncontrolled high blood pressure.
• •Uncontrolled serious infection.
• •History of or active autoimmune disease.
• •History or clinical manifestation of clinically significant and severe hematological, renal, hepatic, pulmonary, central nervous, cardiovascular or gastrointestinal disorders.
• •History of an immediate family member (father, mother, brother, or sister) who has had onset of ischemic heart disease before the age of 50 years.
• •High risk of developing a myocardial infarction or coronary death.
• •History of intravenous drug abuse (within the last 12 months).
• •Known allergy to egg or aminoglycoside (gentamicin).
• •History of anaphylaxis or severe allergic reaction.
• •Subjects undergoing treatment for tuberculosis infection or disease.
• •Chronic administration of systemic immuno-suppressants.