Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Montreal Heart Institute
With
Pfizer
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients with a documented history of hypertension defined as: SBP \> or = 140 mmHg or DBP \> or = 90 mmHg if hypertension untreated or patients currently treated for hypertension.
Documented CAD or diabetes or impaired glucose tolerance
Sinus rhythm
You may not be if
Previous intolerance or allergic reaction to an ACE inhibitor, an ARB or dihydropyridine calcium channel blocker
History of angioedema or cough related to previous ACE inhibitor use.
Systolic blood pressure \> 180 mmHg or diastolic blood pressure \> 110 mmHg in untreated patients
Systolic blood pressure \> 160 mmHg or diastolic blood pressure \> 100 mmHg in patients currently treated by an ACE inhibitor or an ARB
Creatinine clearance \< 30 ml/min
Significant liver dysfunction
Current serum potassium \> or = 5 mmol/L or a history of marked ACE inhibitor or ARB induced hyperkalemia resulting in either a serum potassium \> or = 5.5 mmol/L or a life-threatening adverse event.
History of HF or known LVEF \< or = 45%
Bilateral renal artery stenosis (or unilateral if only one kidney)
Unstable angina, myocardial infarction or coronary revascularization within the last 3 months.
Connective tissue disease or chronic inflammatory condition
Active malignancy
Active infection in the last 2 weeks
Inability or any contraindication to perform an exercise test.
