Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Sanofi
With
Bristol-Myers Squibb
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
The following information on clinical trials is provided for information purposes only to allow patients and physicians to have an initial discussion about the trial. This information is not intended to be complete information about the trial, to contain all considerations that may be relevant to potential participation in the trial, or to replace the advice of a personal physician or health professional.
Main criteria are listed hereafter:
Patient hospitalised with ischemic symptoms (last episode within the last 48 hours before randomization) and at least one of the following characteristics of NSTEACS (non-ST-segment-elevation acute coronary syndromes):
* ECG ST or T changes (ST depression or transient elevation of at least 1mm or T wave changes in at least 2 leads)
* Positive troponin (according to local threshold)
You may not be if
Women of child bearing potential who are unwilling or unable to use an acceptable method to avoid pregnancy for the entire study period and for up to 4 weeks after the study WOCBP using a prohibited contraceptive method (not applicable)
Women who are pregnant or breast feeding
Women with a positive pregnancy test on enrolment or prior to study drug administration
Patient with dementia
Persistent ST segment elevation at ECG
Systolic blood pressure \< 100 mmHg
Bilateral stenosis of renal artery
Creatinine clearance \< or = 30ml/mn
Congestive heart failure with symptoms consistent with New York Heart Association (NYHA) class III or IV.
Aortic or mitral valve stenosis
Hypertrophic cardiomyopathy
Connective tissue disease with vascular involvement
Angioplasty, surgery or trauma within the last 3 months
Coronarography or angioplasty planned to be performed or performed before baseline sampling
Febrile (≥ 38°C) disease, known concomitant viral or bacterial infection, chronic auto immune disease, chronic inflammatory disease, known cancer in evolution
Hyperkalemia: serum potassium \> 5.5mmol/l
Sensitivity or intolerance to Angiotensin receptor blockers (ARBs) : olmesartan, candesartan, irbesartan, eprosartan, losartan, telmisartan, valsartan and/or any other ARB currently or previously in development.
Sensitivity or intolerance to Angiotensin-converting Enzyme Inhibitors (ACE-I) : benazepril, captopril, enalapril, lisinopril, trandolapril, ramipril, quinapril, and/or any other ACE-I currently or previously in development.
Chronic steroid or non-steroidal anti inflammatory drugs (NSAIDs) use. Aspirin is permitted.
Treatment with allopurinol or procaïnamide
Concomitant use of potassium sparing diuretics (eg. spironolactone, triamterene or amiloride), potassium preparations or salt substitutes containing potassium
Treatment with Lithium
Immunosupressive medication
Administration of any other investigational drug in the last 30 days before enrolment and during the course of the study
Treatment with ARB or ACE inhibitor within the last 3 days.
Clareo Health | ARCHIPELAGO: Irbesartan in Patients With Acute Coronary Syndrome Without ST Segment Elevation
