Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
National Jewish Health
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Adults (≥18yr) who report a physician's diagnosis of asthma and have taken any asthma medication within the last 2 weeks.
Obesity (Body Mass Index (BMI) ≥40, or ≥35 with comorbidities, as per published guidelines for qualification for bariatric surgery).
Planned weight-loss surgery or structured weight-loss plan.
You may not be if
Tobacco use within one month.
Qualifying lung-functioning.
Qualifying oxygen saturation levels.
Use of systemic corticosteroids (Prednisone) within one month.
Presence of another chronic lung disease besides asthma (COPD, bronchiectasis, ILD, sarcoidosis, etc).
Presence of another chronic systemic inflammatory disease (rheumatoid arthritis or other connective-tissue disease, chronic infection such as osteomyelitis, inflammatory bowel disease, chronic active hepatitis, etc). Subjects with osteoarthritis, stable coronary artery disease, hypertension, or diabetes mellitus will not be excluded.
Presence of malignant neoplasm within the last 3 years (with the exception of non-melanoma skin cancer).
Clinically significant left or right ventricular dysfunction.
Severe pulmonary hypertension (high blood pressure).
Untreated obstructive sleep apnea:
Subjects with a current diagnosis of sleep apnea not being treated with CPAP or BiPAP will be excluded.
Subjects with a current diagnosis of sleep apnea being treated adequately (as determined by the investigators) will be included.
Prader-Willi syndrome
A known endocrinopathy causing obesity (e.g., Cushing's Syndrome).
Clareo Health | The Effect of Obesity on Lung Functioning
