Safety Study of MVA Smallpox Vaccine in HIV-positive Subjects Who Are Vaccinia Naive

Exclusion Criteria

• •Subjects with a known or suspected history of immunodeficiency (with the exception of HIV infection)
• •Subjects with history or prior exposure to a vaccinia-containing product
• •subjects with current radiation treatment or use of immunosuppressive or antineoplastic drugs (with exceptions)
• •Subjects with concomitant illnesses associated with impairment of immunologic function.
• •subjects with dementia
• •Subjects with malignancy.
• •Subjects with a known history of Cardiac disease, or who have risk factors for ischemic coronary disease, or other abnormalities
• •Current or past history of eczema
• •known allergies to any component of MVA, including eggs or egg products, or allergies to blood products
• •females must not be pregnant and using approved contraceptives.
• •Morbid obesity