Adjuvant Chemotherapy for High Risk Uterine Leiomyosarcoma

Inclusion Criteria

• •≥ 18 years of age
• •high risk uterine LMS, FIGO stage I or II
• •pathology review of LMS high grade and /or mitotic rate greater than or equal to 5 mitoses/10 hpf
• •no longer than 12 weeks from surgical resection of cancer
• •no evidence of residual disease
• •ECOG 0 or 1
• •ANC ≥ 1,500, hemoglobin ≥ 8.0, platelets ≥100,000
• •creatinine ≤ 1.5 x institutional upper limits of normal
• •adequate liver function
• •neuropathy (sensory and motor) ≤ CTC grade 1
• •negative pregnancy test
• •signed consent