Patients with localized leiomyosarcoma (LMS) of extremity, body wall or retroperitoneum
Grade 2 or 3, or high-grade LMS
Tumor size \>5 cm in greatest dimension
Primary tumor amenable to complete resection
There is no age requirement
Participant agrees to receive neoadjuvant doxorubicin and ifosfamide combination chemotherapy
If pre-operative radiation is administered, it must be administered after chemotherapy. Post-operative radiation may be administered
Archival tumor tissue (either frozen sample, tissue block containing tumor, or minimum of 4 unstained slides and 1 H\&E stained slide) from diagnostic or pre-treatment biopsy available for study research
Clareo Health | Localized Leiomyosarcoma Biomarker Protocol
