Gemcitabine and Carboplatin Followed by Paclitaxel in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed non-small lung cancer (NSCLC) of any of the following histologic types:
• * Squamous cell
• * Adenocarcinoma
• * Large cell carcinoma
• * Unspecified
• Evidence of at least 1 of the following criteria:
• * Newly diagnosed inoperable stage IIIB (pleural effusion) disease
• * Patients with stage III disease who are unable to undergo combined modality therapy
• * Stage IV disease
• * Recurrent non-small cell lung cancer regardless of site
• * Diagnosis based on sputum cytology acceptable if confirmed by an independent pathologic review
• Patients must have measurable or evaluable disease
• * Measurable or evaluable disease must be outside the previous radiation field or a new lesion must be present
• Patients with brain metastases are eligible, provided they are either asymptomatic (no neurological symptoms or signs, no evidence of midline shift), or controlled (i.e., after surgical resection or radiotherapy/radiosurgery), and off all steroid therapy for at least two weeks with no evidence of progression by symptoms or radiologic imaging
• PATIENT CHARACTERISTICS:
• ECOG performance status of 2 or 3 OR HIV-positive OR underwent prior status post organ transplantation
• No active serious infection (except for HIV infection)
• No symptomatic, untreated malignant pericardial effusion
• No congestive heart failure
• No other serious underlying medical condition that would otherwise impair their ability to receive protocol treatment
• Absolute granulocyte count ≥ 1,500/mm\^3
• Platelet count ≥ 100,000/mm \^3
• Creatinine clearance ≥ 40 mL/min
• Creatinine ≤ 1.8 mg/dL
• Bilirubin \< 1.5 mg/dL
• SGOT ≤ 2 times upper limit of normal
• Not pregnant or nursing
• Negative pregnancy test
• Males or females of reproductive potential may not participate unless they have agreed to use effective barrier contraceptive methods
• No prior malignancy within the past 5 years except for adequately treated basal cell or squamous cell skin cancer or carcinoma in situ of the cervix
• PRIOR CONCURRENT THERAPY:
• See Disease Characteristics
• Prior chemotherapy is not allowed
• At least three weeks since prior radiotherapy and recovered from all toxicities
• At least three weeks must have elapsed from major surgery and recovered from all adverse effects of surgery
• No prior colony-stimulating factors or interferon
• No concurrent hormonal, biologic, or radiotherapy to measurable lesions
• * Patients may receive concurrent palliative radiotherapy to small-field nonmeasurable sites of disease (e.g., painful bony metastases)