Long-Term Safety Evaluation Of Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain

Exclusion Criteria

• •Pregnant, lactating, or planning to become pregnant.
• •Not ambulatory.
• •Participated in another trial with an investigational drug in the past 30 days.
• •Taking opioids for the management of drug addiction or cancer-related pain.
• •Severe constipation whereby the subject is at immediate risk of developing serious complications of constipation.
• •Gastrointestinal or pelvic disorders known to affect bowel transit, produce gastrointestinal (GI) obstruction, or contribute to bowel dysfunction.
• •Human Immunodeficiency Virus (HIV)-infected, has active hepatitis, or has ever been infected with hepatitis C.