TOM: Testosterone in Older Men With Sarcopenia

Exclusion Criteria

• •Use of testosterone, anabolic steroids, dehydroepiandrosterone (DHEA), androstenedione or recombinant growth hormone (rGH) in the past year
• •Alcohol or drug abuse
• •Use of anti-convulsants or glucocorticoids (equivalent to prednisone \> 20 mg/day)
• •Prostate cancer, breast cancer or other cancers with life expectancy \< 5 years
• •Limiting neuromuscular, joint or bone disease, or history of stroke with residual neurological problems
• •Any neurological condition that would impact cognitive functioning including:
• •* epilepsy
• •* multiple sclerosis
• •* HIV
• •* Parkinson's disease
• •* stroke
• •* other focal lesion
• •Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) Axis I psychiatric disorder in past year or use of psychotropic medications in 6 months
• •Abnormal prostate examination; PSA \> 4 ng/mL; or BPH symptom score \> 21
• •Unstable angina, New York (NY) class III or IV congestive heart failure or myocardial infarction within 3 months of entry
• •Abnormal laboratory values (at discretion of principal investigator)
• •Untreated thyroid disease; systolic blood pressure \> 160 or diastolic \> 100 mm Hg
• •Body mass index \> 40 kg/m2
• •Untreated severe obstructive sleep apnea