Pilot Study on the Effect of Oral Controlled-Release Alpha-Lipoic Acid on Oxidative Stress in Adolescents With Type 1 Diabetes Mellitus

Inclusion Criteria

• •1. Subjects must be pubertal (defined as Tanner stage II or greater), or post-pubertal, with an upper age limit of 21 years.
• •2. Subjects must have diabetes by 1997 ADA criteria:
• •1. fasting plasma glucose \>= 126 mg/dL, or
• •2. 2 hour postprandial glucose \>= 200 mg/dL
• •3. Subjects must have history of least one auto-antibody associated with T1D, either glutamic acid decarboxylase (GADA) or islet cell autoantigen 512 (ICA512), or history of diabetic ketoacidosis.