Clareo Health | A 16 Week Study to Evaluate the Effect on Insulin Sensitivity of Valsartan (320 mg) and Hydrochlorothiazide (25 mg) Combined and Alone, in Patients With Metabolic Syndrome
A 16 Week Study to Evaluate the Effect on Insulin Sensitivity of Valsartan (320 mg) and Hydrochlorothiazide (25 mg) Combined and Alone, in Patients With Metabolic Syndrome
MSSBP ≥ 130 mmHg but ≤ 160 mmHg and a MSDBP ≥ 85 mmHg but ≤ 100 mmHg
At least one of the following criteria: - Fasting plasma glucose between 5.9 and 6.9 mmol/L; - Serum triglycerides \> 150 mg/dL; - LDL Cholesterol: - \< 40 mg/dL males; - \< 50 mg/dL females
You may not be if
MSSBP\> 180 mmHg or MSDBP \> 110 mmHg
Inability to discontinue all prior antihypertensives for a period of 4 weeks.
History of diabetes
History of stroke, transient ischemic attack or myocardial infarction.
Significant weight change \> 10 lbs during screening period
Patients taking a diuretic for 3 months prior to screening.
