Effect of Losartan on Retinal Endothelial Function in Patients With Essential Hypertension

Exclusion Criteria

• •Secondary forms of hypertension
• •Advanced damage of vital organs (grade III and IV retinopathy)
• •History of serious hypersensitivity reaction to AT1-receptor blockers
• •Actual or anamnestic alcohol- or drug abuse.
• •Smokers or ex-smokers \< 1 year.
• •Patients with Diabetes mellitus (oral medication or insulin).
• •Patients with arterial fibrillation or AV-Block (II° or more).
• •Patients with anamnestic myocardial infarction.
• •Patients with instable angina pectoris including EcG-aberrations or cardiac insufficiency NYHA III or IV.
• •History of malignancy (unless a documented disease-free period exceeding 10 years is present) with teh exception of basal cell carcinoma of the skin
• •History of allograft transplantation
• •Therapy with not approved concomitant medication, or participation in a clinical study within 4 weeks preceding treatment start.
• •Disease which interfere with the pharmacodynamics and pharmacokinetics of the study drug.
• •Liver-or kidney disease with SGOT, GPT, g-GT, AP, bilirubin and creatinin or above 200% of standard.
• •Patients, who are not sufficiently compliant, or patients, who are not capable or willing to appear for controlling vistas.
• •Presumed risk of transmission of HIV or hepatitis via blood from the participant