Evaluation of an Asthma Treatment Strategy Based on Exhaled Nitric Oxide Measurements in Adolescents

Exclusion Criteria

• •Adherence to controller medication between Visits 1 and 2 is less than 25%. More information on this criterion can be found in the DAIT ICAC-01 protocol.
• •Determined to have mild intermittent asthma at Visit 1
• •Have had a life-threatening asthma exacerbation requiring intubation, mechanical ventilation, or resulting in a hypoxic seizure in the 5 years prior to study entry
• •Have significant medical illnesses other than asthma. More information on this criterion can be found in the DAIT ICAC-01 protocol.
• •Unable to use a metered-dose inhaler for administration of a beta-agonist rescue medication or a dry powder inhaler for the administration of asthma controller regimens
• •Known hypersensitivity to any medications commonly used for the treatment of asthma
• •Have not completed a home evaluation within 4 weeks of study screening
• •Currently participating in another asthma-related drug or intervention study, or have participated in another asthma-related drug or intervention study in the month prior to study entry
• •Does not sleep at least 4 nights per week in one home
• •Lives with a foster parent (not applicable if patient is able to provide informed consent)
• •Does not have access to a phone
• •Requires certain medications. More information on this criterion can be found in the DAIT ICAC-01 protocol.
• •Urine cotinine level above 100 ng/ml at study screening
• •Pregnant or breastfeeding