LMB-2 Immunotoxin in Treating Young Patients With Relapsed or Refractory Leukemia or Lymphoma

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed diagnosis of 1 of the following:
• * Non-Hodgkin's lymphoma, including the following subtypes:
• * Lymphoblastic lymphoma
• * Burkitt's lymphoma
• * Large cell lymphoma
• * Adult T-cell leukemia/lymphoma
• * Cutaneous T-cell lymphoma
• * Peripheral T-cell lymphoma
• * Hodgkin's disease
• * Acute myeloid leukemia
• * Chronic myelogenous leukemia
• * Acute lymphoblastic leukemia (ALL)
• * More than 5% blasts in the bone marrow (i.e., M2 marrow classification)
• * Acute hybrid leukemia, including the following subtypes:
• * Mixed lineage leukemia
• * Biphenotypic leukemia
• * Undifferentiated leukemia
• CD25-positive (CD25+) disease, meeting 1 of the following criteria:
• * More than 15% of malignant cells are CD25+ by immunohistochemistry with anti-CD25 antibody
• * More than 30% of malignant cells from a site are CD25+ by fluorescence-activated cell sorting analysis
• Measurable or evaluable disease
• Relapsed or refractory disease after at least 1 standard chemotherapy regimen AND 1 salvage regimen
• No available alternative curative therapies
• Ineligible for or refused hematopoietic stem cell transplantation OR disease activity that prohibits the required time to identify a suitable stem cell donor
• No CNS leukemia or lymphoma, as evidenced by any of the following criteria:
• * Cerebrospinal fluid (CSF) WBC \> 5/µl AND confirmation of CSF blasts
• * Cranial neuropathies secondary to underlying malignancy
• * CNS lymphoma detected by radiological imaging
• * Prior CNS involvement with no current evidence of CNS malignancy allowed
• No isolated testicular ALL
• PATIENT CHARACTERISTICS:
• Age
• 6 months to 21 years
• Performance status
• ECOG 0-3 (≥ 12 years of age)
• Lansky 40-100% (\< 12 years of age)
• Life expectancy
• Not specified
• Hematopoietic
• Pancytopenia due to disease allowed
• For patients without bone marrow involvement:
• * Absolute neutrophil count \> 1,000/mm\^3
• * Platelet count \> 50,000/mm\^3 (transfusion independent)
• Hepatic
• Bilirubin ≤ 2.0 mg/dL
• AST and ALT ≤ 5 times upper limit of normal
• Hepatitis B surface antigen negative
• Hepatitis C antibody negative
• Renal
• Creatinine clearance ≥ 60 mL/min OR
• Creatinine, meeting the following age-related criteria:
• * ≤ 0.8 mg/dL (≤ 5 years of age)
• * ≤ 1.0 mg/dL (6 to 10 years of age)
• * ≤ 1.2 mg/dL (11 to 15 years of age)
• * ≤ 1.5 mg/dL (\> 15 years of age)
• Calcium 2.0-2.9 mmol/L
• Cardiovascular
• Ejection fraction ≥ 45% by MUGA OR
• Shortening fraction ≥ 28% by echocardiogram
• Pulmonary
• Oxygen saturation ≥ 90%
• Other
• Sodium 130-150 mmol/L
• Potassium 3.0-5.5 mmol/L
• Magnesium 0.5-1.23 mmol/L
• HIV negative
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• No clinically significant unrelated systemic illness that would preclude study participation
• No conditions that would preclude study compliance
• No serum that neutralizes \> 75% of the activity of 1 μg/mL of LMB-2 immunotoxin in tissue culture (due to either anti-toxin or anti-mouse immunoglobulin G antibodies)
• No active graft-vs-host disease (i.e., off immunosuppression)
• PRIOR CONCURRENT THERAPY:
• Biologic therapy
• Prior autologous bone marrow transplantation (BMT) allowed
• At least 100 days since prior allogeneic BMT
• At least 1 week since prior colony-stimulating factors (e.g., filgrastim \[G-CSF\], sargramostim \[GM-CSF\], or epoetin alfa)
• Chemotherapy
• At least 2 weeks since prior chemotherapy (4 weeks for nitrosoureas) except intrathecal chemotherapy
• No other concurrent chemotherapy
• Endocrine therapy
• Concurrent corticosteroids allowed provided the dose has been stable for the past week and does not increase during study treatment
• * Tapering or discontinuation of steroids allowed
• Radiotherapy
• At least 3 weeks since prior radiotherapy unless \< 10% of marrow is irradiated and measurable disease exists outside the radiation port
• Surgery
• Not specified
• Other
• Recovered from all prior therapy
• At least 30 days since prior investigational agents
• Concurrent oral supplementation to maintain normal electrolyte levels allowed
• No concurrent anticoagulation therapy for disease-related conditions
• No other concurrent investigational agents