Finding studies
Finding studies
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Lead
British Columbia Cancer Agency
With
OBJECTIVES: * Determine the safety of inositol for the prevention of lung cancer in patients with bronchial epithelial dysplasia who are current or former smokers. * Determine the potential efficacy of this drug in regression of existing dysplastic lesions or prevention of appearance of new dysplastic lesions in these patients. * Determine whether intake of this drug can facilitate smoking cessation in patients who are current smokers. OUTLINE: This is a dose-escalation study. Patients receive oral inositol twice daily. Treatment continues for 1 or 3 months in the absence of disease progression or unacceptable toxicity. Cohorts of 3-12 patients receive escalating doses of inositol until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 3 of 12 patients experience dose-limiting toxicity. Once the MTD is determined, 10 patients are treated with inositol twice daily at the MTD for 3 months in the absence of disease progression or unacceptable toxicity. Patients are followed at 1 month. PROJECTED ACCRUAL: A total of 3-28 patients will be accrued for this study.
Age
40–74
Sex
ALL
Healthy volunteers
Not accepted