Study of Neurologic Progression With Motexafin Gadolinium and Radiation Therapy (SMART)

Exclusion Criteria

• •Liver metastases;
• •Extracranial metastases in two or more organs;
• •Known leptomeningeal metastases or subarachnoid spread of tumor;
• •Prior whole brain radiation;
• •Plan to use radiosurgery or radiation boost after completion of WBRT;
• •Planned chemotherapy during study treatment (prior and subsequent chemotherapy is allowed);
• •Prior total resection of a single brain metastasis;
• •Laboratory values as follows:
• •LDH \> 1.3 x upper limit of normal (ULN); ANC \< 1500 /mm³; Platelets \< 50,000 /mm³; Creatinine \> 2.0 mg/dL; AST or ALT \> 2 x ULN; Total bilirubin \> 2 x ULN;
• •Women who are pregnant or lactating