Chemotherapy, Tirapazamine, and Radiation Therapy in Treating Patients With Non-Small Cell Lung Cancer

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Histologically or cytologically confirmed primary bronchogenic non-small cell lung cancer
• •* Adenocarcinoma
• •* Large cell carcinoma
• •* Squamous cell carcinoma
• •Stage IIIA or IIIB disease (T1-4, N2-3)
• •* Mediastinal lymph nodes at least 2 cm in diameter by radiography sufficient to stage N2-3 (must be node positive \[cytologically or histologically confirmed\] if largest mediastinal node is less than 2 cm in diameter) OR
• •Selected stage IIB disease (T3, N0 or T3, N1 with a medical condition that precludes surgery)
• •* No malignant pleural effusion
• •Measurable or evaluable disease by chest x-ray or CT scan
• •* No metastatic disease
• •PATIENT CHARACTERISTICS:
• •Age:
• •18 and over
• •Performance status:
• •Zubrod 0-2 OR
• •ECOG 0-2
• •Life expectancy:
• •Not specified
• •Hematopoietic:
• •WBC at least 3,500/mm\^3
• •Platelet count normal
• •Hepatic:
• •Not specified
• •Renal:
• •Creatinine clearance at least 60 mL/min
• •Cardiovascular:
• •No uncontrolled congestive heart failure
• •No unstable angina
• •No unstable cardiac arrhythmias
• •Pulmonary:
• •FEV\_1 at least 1.0 L
• •Other:
• •Not pregnant or nursing
• •Negative pregnancy test
• •Fertile patients must use effective contraception
• •No clinically significant hearing loss
• •PRIOR CONCURRENT THERAPY:
• •Biologic therapy:
• •Not specified
• •Chemotherapy:
• •No prior chemotherapy for lung cancer
• •Endocrine therapy:
• •Not specified
• •Radiotherapy:
• •No prior radiotherapy for lung cancer
• •Surgery:
• •See Disease Characteristics