CI-1040 in Treating Patients With Advanced Breast, Colon, Pancreatic, or Non-Small Cell Lung Cancer

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically or cytologically confirmed metastatic or inoperable non-small cell lung, breast, or colon cancer or duct cell carcinoma of the exocrine pancreas
• Bidimensionally measurable lesions that are not previously irradiated
• * New lesions that have developed in a previously irradiated field may be used as measurable disease
• No brain metastases
• * Patients with prior brain metastases are allowed provided they have undergone prior resection of metastases and/or 1 prior course of cranial irradiation, have no new sites of brain metastases since then, have no worsening CNS symptoms, and have discontinued prior corticosteroids for at least 30 days
• Hormone receptor status:
• * Not specified
• PATIENT CHARACTERISTICS:
• Age:
• 18 and over
• Sex:
• Not specified
• Menopausal status:
• Not specified
• Performance status:
• ECOG 0-2
• Life expectancy:
• Not specified
• Hematopoietic:
• Absolute neutrophil count at least 1,500/mm\^3
• Platelet count at least 100,000/mm\^3
• Hepatic:
• Bilirubin no greater than 2 times upper limit of normal (ULN)
• AST or ALT no greater than 2 times ULN (5 times ULN if due to liver involvement)
• Renal:
• Creatinine no greater than 1.5 times ULN
• Other:
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception during and for 30 days after study participation
• Capable of swallowing intact study medication capsules
• Capable of following instructions regarding study medication or has daily caregiver to administer study medication
• No concurrent serious infection
• No life-threatening illness unrelated to tumor
• No other prior or concurrent malignancy within the past 3 years except nonmelanoma skin cancer or carcinoma in situ of the cervix
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• At least 2 weeks since prior immunotherapy or biologic therapy
• Chemotherapy:
• At least 4 weeks since prior cytotoxic chemotherapy
• No more than 1 prior cytotoxic chemotherapy regimen for metastatic non-small cell lung or colon cancer
• No more than 2 prior cytotoxic chemotherapy regimens for breast cancer
• No prior cytotoxic chemotherapy for pancreatic cancer
• Endocrine therapy:
• See Disease Characteristics
• At least 2 weeks since other prior hormonal therapy
• Radiotherapy:
• See Disease Characteristics
• At least 3 weeks since prior radiotherapy and recovered
• No concurrent radiotherapy
• Surgery:
• See Disease Characteristics
• Other:
• No other concurrent anticancer agents