Vaccine Therapy Plus Biological Therapy in Treating Adults With Metastatic Solid Tumors

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically confirmed solid tumors potentially expressing mutant ras, including colon, lung, pancreas, thyroid, endometrial, head and neck, testicular, hepatocellular, and melanoma
• Ras mutations must be one of the following point mutations at codon 12:
• * Glycine to cysteine
• * Glycine to aspartic acid
• * Glycine to valine
• Metastatic disease for which no known chemotherapy or radiotherapy would increase survival
• Tumor tissue must be available for determination of ras mutation
• No prior CNS metastases
• PATIENT CHARACTERISTICS:
• Age:
• 18 and over
• Performance status:
• ECOG 0-1
• Life expectancy:
• More than 3 months
• Hematopoietic:
• WBC at least 2,000/mm\^3
• Platelet count at least 100,000/mm\^3
• Hepatic:
• Bilirubin no greater than 2.0 mg/dL
• SGOT/SGPT no greater than 4 times normal
• No hepatitis B or C infection
• Renal:
• Creatinine no greater than 2.0 mg/dL
• Cardiovascular:
• No active ischemic heart disease (New York Heart Association class III or IV)
• No myocardial infarction within the past 6 months
• No history of congestive heart failure, ventricular arrhythmias, or other arrhythmias requiring therapy
• Immunologic:
• No prior allergy to eggs
• No prior autoimmune disease, including the following:
• * Autoimmune neutropenia, thrombocytopenia, or hemolytic anemia
• * Systemic lupus erythematosus, Sjogren's syndrome, or scleroderma
• * Myasthenia gravis
• * Goodpasture syndrome
• * Addison's disease, Hashimoto's thyroiditis, or active Graves' disease
• Other:
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• HIV negative
• No other active malignancy except curatively treated carcinoma in situ of the cervix or basal cell skin cancer
• No active infection requiring antibiotics
• No medical condition that would preclude study
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• At least 4 weeks since prior immunotherapy and recovered
• Chemotherapy:
• See Disease Characteristics
• At least 4 weeks since prior chemotherapy and recovered
• Endocrine therapy:
• At least 4 weeks since prior steroids and recovered
• Radiotherapy:
• See Disease Characteristics
• At least 4 weeks since prior radiotherapy and recovered
• Surgery:
• Not specified