Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically diagnosed solid tumor (i.e., breast and ovarian epithelial carcinomas) or lymphoma
• * Slides reviewed at the NCI Laboratory of Pathology
• Failure on therapy of proven efficacy for the disease
• * Prior therapy not required for the following metastatic diseases:
• * Melanoma
• * Non-small cell lung cancer
• * Renal cell carcinoma
• No brain metastases
• * Primary brain tumors (such as glioblastoma multiforme) with stable neurologic deficits allowed
• Measurable or evaluable disease required
• * Demonstrated by physical exam or on radiograph within 2 weeks prior to initiation of treatment OR
• * Elevated PSA associated with prostate cancer
• * Other marker-only disease ineligible
• PATIENT CHARACTERISTICS:
• Age:
• Over 18
• Performance status:
• ECOG 0-2
• Life expectancy:
• At least 3 months
• Hematopoietic:
• WBC at least 3,000/mm\^3
• Platelet count at least 100,000/mm\^3
• Hematocrit at least 27%
• Hepatic:
• Liver function tests no greater than 2 times upper limit of normal
• Bilirubin normal
• PT or PTT no greater than 1.25 times upper limit of normal
• Clotting parameters normal
• No concurrent anticoagulants other than 1 mg of warfarin per day for prophylaxis
• Renal:
• Creatinine no greater than 1.5 mg/dL OR
• Creatinine clearance at least 45 mL/min
• No kidney obstruction
• Cardiovascular:
• No cardiac conduction defect requiring antiarrhythmics
• No evidence of myocardial infarction or other myocardial damage within past 6 months
• Other:
• HIV negative
• No concurrent infection
• No guaiac-positive stool test
• No neuropathy greater than grade I (unless associated with fixed-deficit primary brain tumors)
• Not pregnant or nursing
• Fertile patients must use effective contraception during and for 2 months after study
• PRIOR CONCURRENT THERAPY:
• Recovery from prior therapy required
• Biologic therapy:
• At least 4 weeks since prior biologic therapy
• Chemotherapy:
• At least 4 weeks since prior chemotherapy (6 weeks since mitomycin, nitrosoureas, or carboplatin)
• No progression on carboxyamidotriazole or paclitaxel
• At least 6 months between treatment and relapse
• Endocrine therapy:
• At least 4 weeks since prior hormonal therapy
• No concurrent corticosteroids except as physiologic replacement
• Radiotherapy:
• At least 4 weeks since prior radiotherapy
• Surgery:
• Not specified
• Other:
• At least 1 week since prior therapeutic antibiotics
• Concurrent prophylactic antibiotics allowed except imidazole antifungals (e.g., ketoconazole, fluconazole)
• No concurrent calcium channel blockers