Phase II Study of Pallidotomy for Parkinson Disease

Inclusion Criteria

• •PROTOCOL ENTRY CRITERIA:
• •-Disease Characteristics--
• •Idiopathic Parkinson disease Hoehn and Yahr stage III or worse during "off" periods
• •Responsive to levodopa by history or exam Sub-optimal clinical response to maximal medication Medication optimized for at least 4 weeks prior to entry
• •No atypical or secondary disease, e.g.:
• •No history of cerebrovascular accident
• •No cerebellar involvement
• •No severe brain atrophy on magnetic resonance imaging
• •No Mattis Dementia Rating Scale score less than 116
• •No dementia meeting Diagnostic and Statistical Manual of Mental Disorders-IV criteria
• •No Hamilton Depression Rating Scale score greater than 10
• •No Hamilton Anxiety Scale score greater than 14
• •-Patient Characteristics--
• •Other: No medical contraindication to surgery, e.g.:
• •Diabetes
• •Cardiopulmonary disease