Docetaxel in Treating Patients With Solid Tumors

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically proven unresectable solid tumors (e.g., lung, breast, head and neck, bladder)
• Clinically suitable for treatment with single agent docetaxel
• Caucasian (at least 2 generations originating in any of the original peoples of Europe, North Africa, or the Middle East) OR
• African American (at least 2 generations originating in any of the black racial groups of Africa)
• PATIENT CHARACTERISTICS:
• Age:
• 18 and over
• Performance status:
• 0-2
• Hematopoietic:
• Granulocyte count at least 1,500/mm3
• Platelet count at least 100,000/mm3
• Hepatic:
• Bilirubin no greater than upper limit of normal (ULN)
• AST no greater than 1.5 times ULN AND
• Alkaline phosphatase no greater than 2.5 times ULN
• Renal:
• BUN no greater than 1.5 times ULN
• Creatinine no greater 1.5 times ULN
• Other:
• Not pregnant or nursing
• Fertile patients must use effective contraception
• PRIOR CONCURRENT THERAPY:
• Biologic therapy:
• No prior bone marrow transplantation
• Chemotherapy:
• No prior docetaxel
• Prior paclitaxel allowed
• 1 or 2 prior chemotherapy regimens allowed
• At least 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin)
• No other concurrent chemotherapy
• Endocrine therapy:
• No concurrent hormones for disease related conditions
• Concurrent steroids for adrenal failure allowed
• Radiotherapy:
• At least 2 weeks since prior radiotherapy
• Palliative radiotherapy allowed except whole brain irradiation for CNS disease
• Surgery:
• Not specified
• Other:
• At least 48 hours since prior or concurrent ethanol (CYP3A enzyme inducer) or grapefruit juice (CYP3A enzyme inhibitor)
• At least 7 days since prior or concurrent CYP450 inducing drugs:
• * Antiseizure medications: phenobarbital, phenytoin, carbamazepine, or lamotrigine
• * Anti-TB therapy: rifampin, isoniazid, or sulfinpyrazone
• At least 7 days since prior or concurrent CYP450 3A inhibiting drugs:
• * Macrolides: erythromycin, clarithromycin, azithromycin, or roxithromycin
• * Azoles: ketoconazole, fluconazole, or itraconazole
• * Other antibiotics: metronidazole or chloramphenicol
• * Anti-HIV drugs: ritonavir, indinavir, nelfinavir, or delavirdine
• * Immunosuppressive agents: cyclosporine
• * Antidepressant agent: nefazodone