Combination Chemotherapy Plus Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Myeloproliferative Disorders

Inclusion Criteria

• •DISEASE CHARACTERISTICS:
• •Idiopathic myelofibrosis (IMF) with at least 1 poor prognosis characteristic, including but not limited to:
• •* Hemoglobin less than 10 g/dL
• •* Platelet count less than 100,000/mm\^3
• •* Hepatomegaly (i.e., palpable liver edge 5 cm below costal margin)
• •* Clinical requirement for splenectomy
• •Other myeloproliferative disorders in an IMF like myelofibrotic state eligible
• •No evidence of leukemic progression, e.g.:
• •* Greater than 15% peripheral blood blasts
• •* Fever or bone pain of unknown origin
• •* Rapidly progressing splenomegaly
• •No other causes for myelofibrosis, such as:
• •* Collagen vascular disorder
• •* Lymphoma
• •* Granulomatous infection
• •* Metastatic carcinoma
• •* Hairy cell leukemia
• •* Myelodysplastic syndrome
• •No active central nervous system disease
• •One of the following donor/patient pairings is required:
• •* Donor status:
• •* Genotypic or phenotypic HLA-matched relative
• •* Maximum patient age of 65
• •* One antigen HLA-mismatched relative, HLA-matched unrelated donor, or one antigen HLA-mismatched unrelated donor
• •* Maximum patient age of 55
• •Transplant on this protocol allowed for patients registered on protocol FHCRC-1106.00
• •PATIENT CHARACTERISTICS:
• •Age:
• •65 and under
• •Performance status:
• •Not specified
• •Hematopoietic:
• •See Disease Characteristics
• •Hepatic:
• •Bilirubin no greater than 2 times normal
• •SGPT no greater than 4 times normal
• •Renal:
• •Creatinine no greater than two times normal OR
• •Creatinine clearance at least 50%
• •Cardiovascular:
• •Ejection fraction at least 50%
• •Cardiac evaluation required if signs or symptoms of coronary artery disease or congestive heart failure
• •Other:
• •HIV negative
• •No active infection
• •Patients excluded from this protocol are referred to protocol FHCRC-179.05
• •PRIOR CONCURRENT THERAPY:
• •Biologic therapy:
• •Not specified
• •Chemotherapy:
• •Not specified
• •Endocrine therapy:
• •Not specified
• •Radiotherapy:
• •Not specified
• •Surgery:
• •Not specified