13-Cis Retinoic Acid With or Without Vitamin E for Prevention of Lung Cancer

Exclusion Criteria

• •1. Patients must not have a current or past history of cancer within the past 5 years with the exception of surgically cured head and neck cancer or surgically cured Stage I or II lung cancer \> 36 months from diagnosis or skin cancer or in situ cancers.
• •2. Patients must have no serious intercurrent illness including insulin dependent diabetes mellitus or hypercholesterolemia (\>239mg/dl) / hypertriglyceridemia (\>149mg/dl).
• •3. Patients must not have evidence of clinically active coronary artery disease including myocardial infarction within 6 weeks, chest pain or poorly controlled congestive heart failure or any other serious medical condition, which would preclude a patient from undergoing a bronchoscopy.
• •4. Patients must not have cardiac dysrhythmia that is potentially life threatening such as ventricular tachycardia, multifocal premature ventricular contractions or supraventricular tachycardias with a rapid ventricular response. Well controlled atrial fibrillation or rare (\<2/minute) premature ventricular contractions are not exclusionary
• •5. Chest x-ray must not show evidence of tumor.
• •6. Patients must not be taking vitamin A or E supplements
• •7. Patients must not be taking tetracycline or minocycline.
• •8. Patients who have had prior chemotherapy or radiation therapy.
• •9. Women who are pregnant are ineligible