The Effects of Anti-HIV Drugs in HIV-Infected Patients Who Do Not Have AIDS

Exclusion Criteria

• •Co-existing Condition:
• •Patients with the following symptoms and conditions are excluded:
• •Severe malabsorption.
• •Current AIDS-related opportunistic infection, AIDS dementia, AIDS-wasting syndrome, or an AIDS-related malignancy other than minimal Kaposi's sarcoma disease.
• •Current medical problems that may interfere with the evaluation of AZT or increase the potential toxicity of AZT (e.g., significant liver disease, diabetes, significant cardiovascular disease, seizure disorders, lymphoma, acute or chronic pancreatitis, or febrile illness).
• •Current diagnosis of malignancy for which systemic therapy would be required during study.
• •Concurrent Medication:
• •Excluded:
• •Ganciclovir, foscarnet, chronic acyclovir, or probenecid.
• •Other proven or alleged antiretroviral or anti-HIV drugs.
• •Biologic response modifiers.
• •Valproic acid.
• •Systemic cytotoxic chemotherapy.
• •Steroids.
• •Concurrent Treatment:
• •Excluded:
• •Radiation therapy.
• •Patients with the following prior conditions are excluded:
• •Prior AIDS-related opportunistic infection, AIDS dementia, AIDS-wasting syndrome, or an AIDS-related malignancy other than minimal Kaposi's sarcoma disease.
• •History of medical problems that may interfere with the evaluation of AZT or increase the potential toxicity of AZT (e.g., significant liver disease, diabetes, significant cardiovascular disease, seizure disorders, lymphoma, acute or chronic pancreatitis, or febrile illness).
• •History of peripheral neuropathy (patients with prior AZT treatment only).
• •Prior Medication:
• •Excluded:
• •Prior ddI therapy.
• •Less than 26 weeks of prior AZT (in patients with ongoing AZT therapy only).
• •Ganciclovir, foscarnet, chronic acyclovir, or probenecid.
• •Cytotoxic chemotherapy within 1 month prior to study entry.
• •Acute therapy for an infection or other medical illness within 14 days prior to study entry.
• •History of alcohol abuse (patients with prior AZT treatment).