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NCT06797050
The aim of the present study is to improve cognitive processes that are frequently impaired in children characterised by neuromotor impairment, such as the skills of visual-perceptual analysis and selective attention, working memory, narrative organisation, logical-inferential reasoning and motor planning. For this purpose, a task of reordering figurative stories and action sequences, which include the aforementioned processes, will be used through an innovative Learning by Teaching training paradigm with a social robot. Furthermore, the study aims to verify the children's level of behavioural, cognitive and emotional engagement during the interaction with the social robot and to test the generalisation effects of the intervention on other processes, such as working memory, inhibition and planning.
NCT04036331
The purpose of this research is to determine the effectiveness of a coordinated program (Dyad Plus) that would help to facilitate self-monitoring, positive communication, joint problem solving, and social support to increase physical activity, healthy eating, and weight loss. Participants of the Brenner FIT (Families In Training) pediatric weight management program and their parent/guardian will co-enroll in weight loss programs. Parents/guardians will receive the components of By Design Essentials.
NCT06309121
This study investigates the effects of a postbiotic combination called ABB C3 on reducing body fat and improving metabolic health in children and teenagers. The study consists of a 3-month trial with half participants taking ABB C3 and the other half a placebo, monitoring body composition and blood markers. Afterward, participants can continue with ABB C3 for an additional 3 months. The goal is to determine if ABB C3 is a safe and effective way to help young people improve their health by reducing body fat.
NCT03369691
The study will examine the mechanisms linking race, stress and biobehavioral factors to energy balance and obesity in both natural and controlled environments in African-American and Caucasian adolescent females. A Hispanic/Latina cohort has recently been added with permission for the sponsor.
NCT07252687
Breast dysphoria in transmasculine or genderdiverse individuals is a distinct psychological burden associated with depression, anxiety and suicidality. The aim is to systematically investigate the effect of GAHT (gender-affirming hormone therapy) and mastectomy on this form of dysphoria. The primary objective of this study is to analyse and investigate the psychological and physical effects of breast development on trans men or genderdiverse individuals. A secondary objective is to determine the extent to which the stress affects the well-being of trans men depending on the coping strategies used (binding vs. taping).
NCT07285551
The aim of this study is to assess how physiotherapy based on the Rigo Concept, combined with WBV, affects sagittal spinal curvatures, the angle of trunk rotation (ATR), and trunk symmetry in girls with AIS. Participants undergo a 5-day individualized physiotherapy program. The exercises follow the four general principles of the Rigo Concept: three-dimensional postural correction, expansion technique, muscle activation, and integration. Therapy is delivered for 3 hours per day, with three 15-minute breaks. Additionally, participants in the Rigo Concept with WBV group perform exercises in a standing position using two poles while exposed to WBV on a Galileo Med 35 platform (Novotec Medical GmbH, Pforzheim, Germany) at a frequency of 25 Hz, with a peak-to-peak displacement of 2 mm. Each session includes three 3-minute bouts of vibration, with 3-minute rests between them. During WBV, participants perform exercises according to the principles of the Rigo Concept.
NCT07441213
Thoracic hyperkyphosis is a common spinal deformity that may alter the biomechanical and viscoelastic properties of trunk muscles. This comparative study aims to investigate differences in the mechanical properties of selected back and chest muscles between individuals with hyperkyphosis and healthy controls. A total of 88 participants will be categorized based on thoracic kyphosis angle (≥50° hyperkyphosis; \<50° control). The kyphosis angle will be measured using a flexible ruler method. Muscle tone, stiffness, elasticity, and relaxation properties of the trapezius, erector spinae, and pectoralis major muscles will be assessed using a handheld myotonometer. Spinal appearance perception will be evaluated using a kyphosis-specific questionnaire. The study is designed to examine whether differences exist in muscle mechanical properties and whether kyphosis severity is associated with asymmetry in viscoelastic muscle characteristics.
NCT07426588
The study was conducted to compare the effective of thoracic extension exercises and global postural corrective exercises on pain, range of motion and posture among hyperkyphotic individuals.
NCT05832957
Background: Attention deficit hyperactivity disorder (ADHD) is associated with a high risk for driving accidents. Adolescents with ADHD are 1.2 to 4 times more prone to be involved in car accidents. Driving accidents are the leading cause of death among adolescents. Objective: Examining a multidimensional applied intervention based on serious gaming principles to improve the driving capabilities and skills of adolescents with ADHD Methodology: The study will include 90 adolescents (aged 15-18 years old) with ADHD diagnosis who did not yet start driving lessons. Participants will undergo a stratified randomized clinical trial, single-blinded. The stratified randomization process will include gender, age, and medication status. There exist three different intervention modalities: (1) A personalized cognitive-functional intervention- 'Drive-Fun' (group1) (2) educational intervention (group2); and (3) no intervention (group3). Meetings will entail 11 once-a-week sessions. Participants will be evaluated before intervention (baseline), after the intervention, and at a 6-month follow-up. Evaluations will include simulated driving skills, meta-cognitive abilities, eye tracking, and brain activity (EEG) measures. The evaluation and the intervention will be conducted by two certified occupational therapists. Participants and the therapist performing the evaluations will be blinded to group type and intervention. The potential scientific contribution of the proposed research: Given the great risks of injury to adolescents with ADHD and other road users, it is important to identify dangerous driving behaviors as well as develop methods that can lead to better driving skills and a safer driving experience. It is anticipated that evidence will be presented by the evaluation battery that the personalized intervention program developed will significantly improve potential driving skills on the simulator and hopefully also actual driving.
NCT07365891
The goal of this study is to find out how well adolescents in Dutch-speaking secondary schools in Brussels can recognize emotional neglect, and how this relates to their intention to seek help. The main research questions are: 1. How well do adolescents recognize situations of emotional neglect, and do boys and girls differ in their recognition? 2. Does recognition of emotional neglect predict adolescents' intention to seek help? This study is conducted through an online survey. Participants will read one of four short written stories about an adolescent experiencing emotional neglect. The stories vary by gender (boy or girl) and by the clarity of the neglect (clear or ambiguous). After reading, participants answer questions about the story, including their thoughts and how they might respond in a similar situation. They also answer questions about their own experiences and attitudes toward help-seeking.
NCT07368166
Population-based and clinical studies indicate that a substantial proportion of children and adolescents are exposed to one or more potentially traumatic events (PTEs) Approximately 16 % of those affected by childhood trauma go on to develop post-traumatic stress disorder (PTSD), with an even higher proportion experiencing subclinical levels of post-traumatic stress symptoms (PTSS). In Switzerland, over half of adolescents report exposure to at least one PTE, with 4.2 % meeting diagnostic criteria for PTSD. PTSD frequently impacts young people's social and educational functioning, often impairing their ability to engage in everyday life activities that are important or meaningful to them. Although the psychological consequences of PTSD are well documented, there is limited empirical understanding of how PTSS specifically affects day-to-day functioning in young people. A key reason for this gap is the absence of a validated instrument specifically designed to assess PTSD-related functional impairment in children and adolescents. To address this need, the PTSD-iMPairment in Adolescent \& Children's Capacity for Thriving (PTSD-iMPACT) measure was developed. This tool aims to systematically assess the extent of PTSD-related functional impairment in children and adolescents across key life domains, such as family, friends, school, apprenticeship, hobbies or media use. The overall aim of this study is to evaluate the psychometric properties of the PTSD-iMPACT questionnaire in a clinical and in a non-clinical sample and to provide an internationally applicable standard instrument for the assessment of PTSD-related functional impairment in trauma-exposed children and adolescents. In the long term, the aim is to ensure that the care and support provided to children and adolescents who experience difficulties in their daily lives due to post-traumatic stress symptoms are sustainably monitored and improved.
NCT07047794
In the sagittal plane, the average kyphosis angle between the superior endplate of the T1 vertebra and the inferior endplate of the T12 vertebra is approximately 40 degrees. A thoracic spine angle greater than 45 degrees is defined as hyperkyphosis. The most common types of hyperkyphosis observed in juveniles and adolescents are Scheuermann's kyphosis, postural hyperkyphosis, and congenital hyperkyphosis. Postural hyperkyphosis is the most prevalent form among these types. It results from the weakness of the muscles responsible for maintaining an upright posture and occurs due to external forces acting on the spine. The curvature of the spine in this condition is not rigid and can generally be corrected when the individual is asked to stand upright. Postural hyperkyphosis is typically seen during adolescence. An increased thoracic kyphosis angle in postural hyperkyphosis can affect scapular kinematics, potentially leading to shoulder pathologies later in life, such as impingement syndrome, rotator cuff tendinopathy, rotator cuff tears, glenohumeral instability, and adhesive capsulitis. Additionally, hyperkyphosis can negatively affect body image and overall quality of life. If it begins in childhood and remains untreated, hyperkyphosis may persist into adulthood and contribute to increased healthcare expenditures. Given the growing prevalence of technology dependence and its association with rising hyperkyphosis incidence, early management of this deformity during juvenile and adolescent periods is essential in terms of both health and economic outcomes. In managing postural hyperkyphosis, it is important to address not only the angular correction of the deformity but also to consider the entire spine within the kinetic chain model. The kinetic chain model is a biomechanical concept that defines the body as a system of interconnected segments. Any dysfunction within one segment of the kinetic chain can affect the quality of movement in both the upper and lower segments. The scapula serves as a foundation within this model, acting as a force transmitter that converts potential energy generated by muscles into kinetic energy in the upper extremity. Hyperkyphosis can lead to scapular protraction and downward rotation, disrupting the normal positioning of the scapula. As a result, joint range of motion, strength, and performance in the upper extremity may be negatively affected. Studies in the literature have shown that scapular positioning and movements play a critical role in upper extremity function. However, no study has been found that specifically investigates the impact of altered scapular position on upper extremity performance in children with thoracic hyperkyphosis. Considering the increasing prevalence of thoracic hyperkyphosis in children due to rising technology addiction, and the potential for this deformity to contribute to upper extremity pathologies in adulthood, identifying its effects is crucial for improving children's physical performance and reducing future healthcare costs.
NCT07331051
Soccer players' agility can be affected by many factors, including nutrition and body composition. The primary objective of our study is to reveal the relationship between nutritional attitudes and anthropometric measurements and agility in elite adolescent soccer players. Our secondary objective is to determine the effect of daily fluid intake and daily sleep duration on anthropometric measurements, nutrition attitude scores, and agility in soccer players. Study was conducted on 51 male soccer players aged 14-18. Information on the soccer players' sociodemographic characteristics and lifestyles was obtained via a questionnaire. Body composition analysis was measured using a Bioelectrical Impedance Analysis (BIA) device, and hand grip strength was measured using a hand grip dynamometer. Height, waist circumference, and hip circumference were measured. Soccer players' attitudes toward nutrition were assessed using the Nutrition Attitude Scale (NAS), and their agility was assessed using the Agility T-Test.
NCT07314801
The FINCARE-Young study aims to investigate the extent and development of financial toxicity in adolescents and young adults with cancer. The primary purpose of this study is to assess the level of financial burden experienced during the acute phase of cancer treatment and after completion of therapy, and to analyze changes over time. In addition, the study seeks to identify sociodemographic, clinical, and socioeconomic factors associated with financial toxicity, as well as its impact on employment and social reintegration. By focusing on young adult cancer survivors, this study addresses an underexplored population and seeks to generate evidence to improve supportive care strategies and reduce long-term financial consequences of cancer.
NCT07308509
Age, body mass index, and modern technological influences predisposed to high prevalence of postural deviations such as forward head posture and thoracic hyperkyphosis, and rounded shoulders among school-aged children. The comprehensive integration of developmental and biomechanical perspectives on these adaptations is limited Upper-body postural adaptations reflect a complex interplay between developmental growth and biomechanical loading. Regular posture assessment in schools and clinical settings is crucial for early detection and culturally tailored prevention. Future longitudinal and cross-cultural studies are essential to establish normative postural values and clarify causal pathways across populations
NCT05763901
While various complex pathologies of the developmental age, such as Infantile Cerebral Palsy or Neuromuscular Diseases, are notoriously considered causes of alteration of locomotor development, it is scarcely known whether conditions much more frequent in the pediatric population, the so-called "Paramorphisms or Dysmorphisms", may be associated with more or less noticeable changes in locomotor development. On a few studies, flat feet and hyperlaxity has been correlated with a motor control delay or poorer motor performance, based on complex clinical tests or on stereophotogrammetry movement analysis. Although promising, these preliminary studies, in addition to not providing information on the possible influence of other paramorphisms, such as varus and valgus of the knees, do not provide conclusive indications. The aim of this study is to investigate, through clinical tests and wearable inertial units, the motor control of a pediatric population affected by Paramorphisms or Dysmorphisms and to compare them with a population of healthy controls, matched by age, taken from the recently developed control data set from Bisi and Stagni.
NCT05574439
Introduction: The increasing prevalence of obesity is particularly pronounced among adolescents. Currently available treatment options consist of structured lifestyle interventions. However, 25 % of adolescents do not respond to lifestyle treatment, why new effective treatment strategies are needed. Therefore, the aim of this study is to investigate the effect of lifestyle interventions combined with the GLP-1 receptor agonist semaglutide to young adults with otherwise treatment resistant obesity. Methods and analysis: This is an investigator-initiated, randomized, placebo-controlled trial. 180-270 young adults (age 18-28) will be recruited from The Childrens Obesity Clinic (TCOC), Department of Pediatrics, Holbæk Hospital. Based on their previous response to the TCOC protocol the participants will be divided in four groups: Group A: Non-responders: 55-85 young adults with obesity (BMI≥30 kg/m2) who have not reduced adiposity, defined as BMI SDS reduction \<0.1, during the structured lifestyle counselling as children. Group B: Insufficient responders: 55-85 young adults who have reduced adiposity, defined as BMI SDS reduction \>0.25, during the structured lifestyle counselling as children but still have obesity as young adults (BMI≥30 kg/m2) Group C: Excellent responders: 35-50 young adults, who have reduced adiposity, defined as BMI SDS reduction \>0.5, during the structured lifestyle counselling as children and no longer have obesity as young adults (BMI\<30 kg/m2) Group D: Population-based reference group (normal weight development): 35-50 young adults, who have participated in The Holbaek Study as children. Group A and B are randomized 2:1 to either semaglutide or placebo for 68 weeks. Group C and D will attend baseline examinations only and not undergo intervention. The primary endpoint is change in BMI from randomization to end-of-treatment. Ethics and dissemination: The trial has been approved by the Danish Medicines Agency (EudraCT 2019-002274-31) and by the ethical committee of the Capital Region of Denmark (H-20039422). The trial will be conducted in agreement with the Declaration of Helsinki and monitored to follow the guidelines for good clinical practice. Results will be submitted for publication in international peer-reviewed scientific journals.
NCT07276178
The aim of this study is to examine the psychometric properties of the Turkish version of the Scoliosis Caregiver Response and Emotional Scale (SCaRES) questionnaire; to evaluate the reliability of the Turkish form and to ensure its usability in clinical and research fields.
NCT07249502
Adolescent Idiopathic Scoliosis is a common musculoskeletal condition characterized by a three-dimensional spinal deformity, affecting approximately 2-4% of adolescents worldwide and occurring more frequently in girls. Beyond spinal curvature, Adolescent Idiopathic Scoliosis can negatively influence physical fitness, muscular strength, respiratory function, postural control, and participation in daily activities. These factors may reduce overall functional capacity and quality of life. Scoliosis-specific corrective exercises, including approaches such as Schroth and The Scientific Exercise Approach to Scoliosis, have been shown to improve postural symmetry, slow curve progression, and enhance respiratory and psychosocial outcomes. However, the effects of these exercises on physical fitness parameters-such as muscle strength, flexibility, motor performance, and cardiorespiratory endurance-remain insufficiently studied. The aim of this study is to investigate the effects of scoliosis-specific corrective exercises on physical fitness parameters in adolescents diagnosed with Adolescent Idiopathic Scoliosis. Measures of strength, flexibility, motor performance, and cardiorespiratory endurance will be assessed before and after the intervention. Findings from this study are expected to contribute to the development of evidence-based conservative treatment protocols focusing not only on curve progression but also on functional capacity and overall fitness in adolescents with scoliosis.
NCT06631313
A prospective, uncontrolled, open-label healthy volunteer study to assess the performance of the PureWick Male and PureWick Flex Female external catheter devices in adolescents