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Polypill and Colchicine for Risk Reduction in Atherosclerotic Cardiovascular Disease

NCT06930885

The EPOCA study (Evaluation of a POlypill and Colchicine for risk reduction in patients with established Atherosclerotic cardiovascular disease) will be a randomized, superiority, parallel, 2x2 factorial, multicenter clinical trial which will include at least 7713 and up to a maximum of 10797 participants with established atherosclerotic cardiovascular disease.

Atherothrombotic DiseasesAtherosclerotic Cardiovascular Disease (ASCVD)

Hospital do Coracao7,713 participantsStarted Jun 2025

Maceió, Alabama, Brazil • Messejana, Ceará, Brazil • Petrolina, Pernambuco, Brazil +10 more locations

COMPLETEDPhase 1

A Study to Evaluate the Effect of Rifampin on the Single-dose Pharmacokinetics (PK) of BMS-986141 in Healthy Subjects

NCT02957448

This study is to evaluate the effect of multiple doses of rifampin on the single-dose PK of BMS 986141 with parameters like Cmax, AUC(INF), AUC(0-T), AUC(0-144h)

Atherothrombotic Diseases

Bristol-Myers Squibb16 participantsStarted Nov 2016

Data from ClinicalTrials.govTerms

Showing 1-2 of 2 trials

RECRUITINGPhase 3

Polypill and Colchicine for Risk Reduction in Atherosclerotic Cardiovascular Disease

NCT06930885

The EPOCA study (Evaluation of a POlypill and Colchicine for risk reduction in patients with established Atherosclerotic cardiovascular disease) will be a randomized, superiority, parallel, 2x2 factorial, multicenter clinical trial which will include at least 7713 and up to a maximum of 10797 participants with established atherosclerotic cardiovascular disease.

Atherothrombotic DiseasesAtherosclerotic Cardiovascular Disease (ASCVD)

Hospital do Coracao7,713 participantsStarted Jun 2025

Maceió, Alabama, Brazil • Messejana, Ceará, Brazil • Petrolina, Pernambuco, Brazil +10 more locations

COMPLETEDPhase 1

A Study to Evaluate the Effect of Rifampin on the Single-dose Pharmacokinetics (PK) of BMS-986141 in Healthy Subjects

NCT02957448

This study is to evaluate the effect of multiple doses of rifampin on the single-dose PK of BMS 986141 with parameters like Cmax, AUC(INF), AUC(0-T), AUC(0-144h)

Atherothrombotic Diseases

Bristol-Myers Squibb16 participantsStarted Nov 2016

Data from ClinicalTrials.govTerms

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Polypill and Colchicine for Risk Reduction in Atherosclerotic Cardiovascular Disease

A Study to Evaluate the Effect of Rifampin on the Single-dose Pharmacokinetics (PK) of BMS-986141 in Healthy Subjects

Polypill and Colchicine for Risk Reduction in Atherosclerotic Cardiovascular Disease

A Study to Evaluate the Effect of Rifampin on the Single-dose Pharmacokinetics (PK) of BMS-986141 in Healthy Subjects