Clinical Trials in Tennessee

Showing 7641-7660 of 15,329 trials

Study of BTK Inhibitor, Ibrutinib in Combination With Carfilzomib in Subjects With Relapsed and Refractory Multiple Myeloma

NCT01962792

A MULTICENTER PHASE 1/2B STUDY OF THE BRUTON'S TYROSINE KINASE INHIBITOR, IBRUTINIB (PCI-32765), IN COMBINATION WITH CARFILZOMIB (KYPROLIS™) IN SUBJECTS WITH RELAPSED OR RELAPSED AND REFRACTORY MULTIPLE MYELOMA

Multiple Myeloma

Pharmacyclics LLC.84 participantsStarted Dec 2013

Duarte, California, United States • Los Angeles, California, United States • Denver, Colorado, United States +14 more locations

COMPLETEDPhase 129 miles

Avelumab in Metastatic or Locally Advanced Solid Tumors (JAVELIN Solid Tumor)

NCT01772004

This is a Phase 1, open-label, dose-escalation trial of avelumab \[antibody targeting programmed death ligand 1 (anti PD-L1)\] with consecutive parallel group expansion in participants with selected tumor indications. New recruitment is open for all active cohorts. Active cohorts: Escalation revised dosing regimen cohort. Closed cohorts: Non-small cell lung cancer (NSCLC, first line), NSCLC (post-platinum), metastatic breast cancer (MBC), colorectal cancer (CRC), urothelial carcinoma (secondary), mesothelioma, gastric/GEJ cancer (first line switch maintenance and second line), and ovarian cancer (secondary and platinum refractory + liposomal doxorubicin), renal cell carcinoma (second line) melanoma and head, neck squamous cell carcinoma (HNSCC), castrate-resistant prostate cancer (CRPC), adrenocortical carcinoma (ACC) urothelial carcinoma (efficacy), gastric/gastroesophageal junction (GEJ) cancer (third line), renal cell carcinoma (RCC, first line) and escalation phase .

Solid Tumors

EMD Serono Research & Development Institute, Inc.1,756 participantsStarted Jan 2013

Goodyear, Arizona, United States • Scottsdale, Arizona, United States • Scottsdale, Arizona, United States +71 more locations

Study of BTK Inhibitor, Ibrutinib in Combination With Carfilzomib in Subjects With Relapsed and Refractory Multiple Myeloma

Avelumab in Metastatic or Locally Advanced Solid Tumors (JAVELIN Solid Tumor)

Find Trials by Condition in Tennessee

Study of MTB-9655, an Inhibitor of ACSS2, in Patients With Advanced Solid Tumors

A Study of Luspatercept (ACE-536) to Treat Anemia Due to Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes

Vinflunine in Hormone Refractory Prostate Cancer (HRPC)

Drug-Drug Interaction Study of Entinostat and Exemestane in Postmenopausal Women With ER+ Breast Cancer

Clinical Trial to Evaluate the Efficacy of OC-02 Nasal Spray on Signs and Symptoms of Dry Eye Disease (The PEARL Study)

Physical Activity Daily - An Internet-Based Walking Program for Patients With Peripheral Arterial Disease

Study to Evaluate the Safety, Tolerability, and Efficacy of Armodafinil as Treatment for Patients With Excessive Sleepiness Associated With Mild or Moderate Closed Traumatic Brain Injury

Phase 2 Efficacy, Safety, and Tolerability Study of Natalizumab in Focal Epilepsy

Autologous Dendritic Cells Loaded With Autologous Tumor Associated Antigens for Treatment of Newly Diagnosed Glioblastoma

Restore EF Observational Study

Randomized Endo-Vein Graft Prospective

Inhibiting Fatty Acid Synthase to Improve Efficacy of Neoadjuvant Chemotherapy

A Study of Gantenerumab in Participants With Prodromal Alzheimer's Disease

Study to Evaluate Safety and Preliminary Efficacy of Tafasitamab With Idelalisib or Venetoclax in R/R CLL/SLL Patients Pretreated With BTKi

Participant Reported Outcomes With Use of Trifarotene 50 μg/g Cream in the Treatment of Moderate Facial and Truncal Acne Vulgaris

Comparative Bioavailability of Risperidone

Study of CAD-9303 in Subjects With Schizophrenia

PREMOD2 With Near Infrared Spectroscopy Sub-study