Clinical Trials in Tennessee

Showing 5981-6000 of 15,329 trials

M3541 in Combination With Radiotherapy in Solid Tumors

NCT03225105

This dose-escalation study evaluated the safety, tolerability, pharmacokinetic (PK), pharmacodynamic, and explore antitumor activity of M3541 in combination with fractionated palliative radiotherapy (RT) in participants with solid tumors with malignant lesions in the thorax, abdominal cavity, head and neck region, or extremities likely to benefit from palliative RT.

Solid Tumors

EMD Serono Research & Development Institute, Inc.15 participantsStarted Sep 2017

Indianapolis, Indiana, United States • St Louis, Missouri, United States • Hackensack, New Jersey, United States +2 more locations

COMPLETEDPhase 129 miles

Galunisertib and Paclitaxel in Treating Patients With Metastatic Androgen Receptor Negative (AR-) Triple Negative Breast Cancer

NCT02672475

This phase I trial studies the side effects and best dose of Galunisertib when given together with paclitaxel in treating patients with androgen receptor negative or triple negative breast cancer that has spread to other places in the body. Some tumors need growth factors, which are made by the body's white blood cells, to keep growing. Galunisertib may interfere with growth factors and help cause tumor cells to die. Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving Galunisertib together with paclitaxel may kill more tumor cells.

Estrogen Receptor NegativeHER2/Neu NegativeProgesterone Receptor Negative+3 more

Vanderbilt-Ingram Cancer Center29 participantsStarted Mar 2016

Nashville, Tennessee, United States

M3541 in Combination With Radiotherapy in Solid Tumors

Galunisertib and Paclitaxel in Treating Patients With Metastatic Androgen Receptor Negative (AR-) Triple Negative Breast Cancer

Find Trials by Condition in Tennessee

A Brief Multimedia Program Affects Parents' Attitudes Toward Physical Punishment

A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD)

First-line Everolimus +/- Paclitaxel for Cisplatin-ineligible Patients With Advanced Urothelial Carcinoma

Open-Label Phase 3 Study to Examine the Long-Term Safety, Tolerability and Efficacy of APL-130277 for the Acute Treatment of "OFF" Episodes in Patients With Parkinson's Disease

Longitudinal Evaluation of Amyloid Risk and Neurodegeneration - the LEARN Study

A Study of BBI608 in Combination With Standard Chemotherapies in Adult Patients With Pancreatic Cancer

Chronic Pain Master Protocol (CPMP): A Study of LY3526318 in Participants With Diabetic Peripheral Neuropathic Pain

Long Term Follow-up of the VisAbility™ Micro Insert System for Presbyopic Patients

Minds Navigating the Diagnosis of Mild Cognitive Impairment

Prospective Database Registry Study of Scoliosis in Children With Cerebral Palsy

Study of Radium-223 Dichloride in Combination With Exemestane and Everolimus Versus Placebo in Combination With Exemestane and Everolimus in Subjects With Bone Predominant HER2 Negative Hormone Receptor Positive Metastatic Breast Cancer

Early Caries Lesion Management Observational Study

A Study to Evaluate Efficacy and Safety of Oral BAY63-2521 in Patients With CTEPH.

To Evaluate Efficacy, Safety, and Tolerability of KX-826 in Male Subjects With Androgenetic Alopecia

Operative Curriculum Gallbladder Surgery

A Dose Escalation and Confirmation Study of PT-112 in Advanced Solid Tumors in Combination With Avelumab

PV-10 in Combination With Pembrolizumab for Treatment of Metastatic Melanoma

Treatment Outcomes in Chronic Hepatitis B Patients on Sequential Therapy With Tenofovir Alafenamide (TAF)