Clinical Trials in Tennessee

Showing 4361-4380 of 15,329 trials

Longitudinal Outcomes of DBS in PD

NCT03582163

Vanderbilt University Medical Center is one of the largest-volume DBS centers in the country. From 2007 through October 2017, 265 Parkinson's disease (PD) patients underwent deep brain stimulation (DBS), 168 of those implanted in subthalamic nucleus (STN) and 97 in globus pallidus interna (GPi). Pre-operatively, each patient is extensively evaluated with a battery of validated motor, cognitive, and mood instruments. This information is stored in RedCAP, a secure online database platform. In an attempt to capture longitudinal outcomes in this population of interest, we will recruit all PD patients two years or more status post DBS who are receiving regular care at Vanderbilt University Medical Center. Study participants will undergo a condensed evaluation of motor function (Unified Parkinson's Disease Rating Scale Part III), cognitive performance (Mini-Mental Status Examination), mood (Beck Depression Inventory), and quality of life (Parkinson's Disease Questionnaire-39). These results will be compared to baseline measures performed pre-operatively, allowing for assessment of interval change. STN and GPi DBS patients will be analyzed separately.

Parkinson Disease

Vanderbilt University Medical Center50 participantsStarted Aug 2018

Nashville, Tennessee, United States

TERMINATEDNA29 miles

Sit Less Program for Patients With Type 2 Diabetes

NCT06457802

This randomized controlled trial aims to evaluate an 8-week intervention designed to reduce sedentary behavior (SB) in patients with type 2 diabetes (T2D) using wearable technology. The intervention involves the use of Fitbit devices to prompt standing/walking breaks, a smart water bottle to encourage hydration-related movement, and tailored text messages for behavior reinforcement. Participants will be assessed at baseline and post-intervention for changes in SB, light physical activity, cardiometabolic markers, and patient-centered outcomes. The study seeks to determine the intervention's acceptability and preliminary efficacy in reducing SB and improving health outcomes in T2D patients.

Type 2 DiabetesSedentary BehaviorSedentary Time+1 more

Vanderbilt University4 participantsStarted Jun 2024

Nashville, Tennessee, United States

Longitudinal Outcomes of DBS in PD

Sit Less Program for Patients With Type 2 Diabetes

Find Trials by Condition in Tennessee

SNV1521 in Participants with Advanced Solid Tumors

DUET Study: A Clinical Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of Orally Administered TERN-501 as Monotherapy and in Combination With TERN-101 in Noncirrhotic Adults With Presumed Non-Alcoholic Steatohepatitis

Clinical Trial to Evaluate Safety and Efficacy of CCX168 in ANCA-Associated Vasculitis

Connect® Lymphoma Disease Registry: A US-Based Prospective Observational Cohort Study

WAveCrest Vs. Watchman TranssEptal LAA Closure to REduce AF-Mediated STroke 2

Trial to Shorten Pharmacologic Treatment of Newborns With Neonatal Opioid Withdrawal Syndrome (NOWS)

An Evaluation of LEO 138559 in Adults With Moderate to Severe Atopic Dermatitis.

Brain Injury Rehabilitation Improving the Transition Experience

The Efficacy and Safety of SerpinPC in Participants with Severe Hemophilia a or Moderately Severe to Severe Hemophilia B

Intervention to Enhance PrEP Persistence

Open-Label Study to Evaluate Safety and Efficacy of CCX168 in Subjects With IGA Nephropathy on Stable RAAS Blockade

A Phase 1/2 Trial of CLN-081 in Patients With Non-Small Cell Lung Cancer

Impact of CardiolRx on Myocardial Recovery in Patients With Acute Myocarditis

A Study of NX-019 in Patients with Advanced, Epidermal Growth Factor Receptor (EGFR) Mutant Cancer

Prognostic Impact of Cardiac Diastolic Function and Coronary Microvascular Function

Safety and Immunogenicity of HIL-214 With Routine Pediatric Vaccines

ALXN1210 Versus Eculizumab in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Eculizumab

Infant Mortality Reduction by the Mass Administration of Azithromycin