Clinical Trials in Tennessee

Showing 2961-2980 of 9,675 trials

Study of AMG 994 Monotherapy and AMG 994 and AMG 404 Combination Therapy in Participants With Advanced Solid Tumors

NCT04727554

The primary objective of this study is to evaluate the safety, tolerability, and maximum tolerated dose (MTD)/maximum tolerated combination dose (MTCD) or recommended phase 2 dose (RP2D) of AMG 994 as monotherapy and AMG 994 in combination with AMG 404 in participants with advanced solid tumors.

Advanced Solid Tumors

Amgen11 participantsStarted Apr 2021

Duarte, California, United States • Detroit, Michigan, United States • Cleveland, Ohio, United States +14 more locations

Active Not RecruitingNA29 miles

PATHFINDER 2: a Multi-Cancer Early Detection Study

NCT05155605

This is a prospective, multi-center interventional study of the GRAIL multi-cancer early detection (MCED) test with return of test results for participants enrolled through healthcare systems in North America. The purpose of this study is to evaluate the safety and performance of the GRAIL MCED test in a population of individuals who are eligible for guideline-recommended cancer screening. In cases with a "cancer signal detected" test result, participants will undergo diagnostic procedures based on the test returned cancer signal origin(s) to determine if they have cancer. The number and types of diagnostic procedures required to achieve diagnostic resolution will be assessed. Participant-reported outcomes will be collected at several time points to assess participants' perceptions about the multi-cancer early detection test. The study will enroll approximately 35,000 and no more than 38,500 participants as defined by eligibility criteria over an anticipated enrollment period of approximately 36 months at up to 40 clinical institutions within North America. Participants will be actively followed for approximately 3 years from the date of their enrollment.

Early Detection of CancerCancer

GRAIL, Inc.35,885 participantsStarted Dec 2021

Auburn, California, United States • Davis, California, United States • Elk Grove, California, United States +53 more locations

Study of AMG 994 Monotherapy and AMG 994 and AMG 404 Combination Therapy in Participants With Advanced Solid Tumors

PATHFINDER 2: a Multi-Cancer Early Detection Study

Find Trials by Condition in Tennessee

Study to Assess Safety, Tolerability and Clinical Activity of BGB-290 in Combination With Temozolomide (TMZ) in Participants With Locally Advanced or Metastatic Solid Tumors

Study to Evaluate Safety and Immunogenicity of COVID-19 Vaccine in Children 6 Months to < 12 Years

Mitigating ACEs in Pediatric Primary Care: Cohort #2 With 6-24 Month Old Children

MP-376 (Aeroquin™, Levofloxacin for Inhalation) in Patients With Cystic Fibrosis

Chimney EndoVascular Aneurysm Sealing Of New Expanded Indication

Phase III Double-blind, Placebo-controlled Study of AZD7442 for Pre-exposure Prophylaxis of COVID-19 in Adult.

Postpartum Glycemia in Women At Risk for Persistent Hyperglycemia

The WEB-IT Clinical Study

Comparing Photon Therapy To Proton Therapy To Treat Patients With Lung Cancer

Long-Term Safety Follow-up Study of Cysteamine Bitartrate Delayed-release Capsules (RP103)

Safety and Efficacy of Brilaroxazine (RP5063) in Schizophrenia

CYPRESS Efficacy and Safety Study Extension

Opioid-Free Anesthetic for Tonsillectomy

The Perceptual Experience of Argus II Users

Study to Assess the Safety of DERMASEAL for Diabetic Foot Ulcers

Genetic Analysis of Attention Deficit Hyperactivity Disorder (ADHD)

Study to Measure Cerebrospinal Fluid Mutant Huntingtin Protein in Participants With Early Manifest Stage I or Stage II Huntington's Disease

Study of Capivasertib in Relapsed or Refractory B-cell Non-Hodgkin Lymphoma