Clinical Trials in Seattle

Showing 3881-3900 of 6,233 trials

Study of Ramucirumab in Ovarian Cancer

NCT00721162

The purpose of this study is to determine if ramucirumab given as monotherapy is effective in the treatment of Persistent or Recurrent Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Carcinoma.

Ovarian CancerFallopian Tube CancerPrimary Peritoneal Carcinoma

Eli Lilly and Company60 participantsStarted Aug 2008

Hollywood, Florida, United States • Orlando, Florida, United States • Chicago, Illinois, United States +10 more locations

COMPLETEDPhase 2< 1 mile

VTX-2337 and Pegylated Liposomal Doxorubicin (PLD) in Patients With Recurrent or Persistent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer

NCT01666444

The purpose of this study is to compare the overall survival of patients treated with VTX-2337 + pegylated liposomal doxorubicin (PLD) versus those treated with PLD alone in women with recurrent or persistent, epithelial ovarian, fallopian tube or primary peritoneal cancer. VTX-2337, a small molecule agonist of Toll-like Receptor 8 (TLR8), activates multiple components of the innate immune system and is being developed as a novel therapeutic agent for use in oncology. Experimental data obtained in an animal model of ovarian cancer supports the combination of VTX-2337 with PLD. In this model, the combination of VTX-2337 and PLD resulted in a significant reduction in tumor growth compared to either agent alone and an increase in the number of T lymphocytes infiltrating the tumor. The combination of PLD and VTX-2337 has been tested in a small number of women with ovarian cancer in a Phase 1b study and appears to be generally well-tolerated.

Epithelial Ovarian CancerFallopian Tube CancerPrimary Peritoneal Cancer

Celgene297 participantsStarted Oct 2012

Phoenix, Arizona, United States • Little Rock, Arkansas, United States • Burbank, California, United States +133 more locations

Study of Ramucirumab in Ovarian Cancer

VTX-2337 and Pegylated Liposomal Doxorubicin (PLD) in Patients With Recurrent or Persistent Epithelial Ovarian, Fallopian Tube or Primary Peritoneal Cancer

Find Trials by Condition in Seattle

Pocket Phantom Tool in Improving Accuracy of Quantitative PET/CT Imaging of Patients With Solid Tumors

A Study in Second Line Metastatic Colorectal Cancer

Pembrolizumab in Treating Patients With Relapsed or Refractory Stage IB-IVB Mycosis Fungoides or Sezary Syndrome

A Study of Emibetuzumab in Non Small Cell Lung Cancer (NSCLC) Participants

A Study of Paclitaxel With or Without Ramucirumab (IMC-1211B) in Metastatic Gastric Adenocarcinoma

The Northwest Coalition for Primary Care Practice Support

Phase 1/2 Dose Escalation Study in Patients With Relapsed or Refractory Waldenstrom's Macroglobulinemia

One Year Study of Rifaximin Delayed Release (DR) Tablets in Crohn's Disease

Study To Assess Efficacy and Safety of Oglemilast in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Safety and Efficacy of Inhaled Insulin in Patients With Diabetes and Asthma or COPD

Evaluate the Efficacy and Safety of Insulin in Patients With Type 2 Diabetes

The Prone Breast Radiation Therapy Trial

Firmagon (Degarelix) Intermittent Therapy

A Study in Participants With Moderate to Severe Psoriasis

An Extension Study to Evaluate the Long-Term Safety of Lampalizumab in Participants With Geographic Atrophy

A Study to Investigate the Safety and Efficacy of PA21 (Velphoro®) and Calcium Acetate (Phoslyra®) in Paediatric and Adolescent Chronic Kidney Disease (CKD) Patients With Hyperphosphataemia

A Study Comparing Dulaglutide With Insulin Glargine on Glycemic Control in Participants With Type 2 Diabetes (T2D) and Moderate or Severe Chronic Kidney Disease (CKD)

MRI to Detect Breast Tumors in Women