Clinical Trials in San Diego

Showing 1521-1540 of 7,028 trials

Clinical and Basic Investigations Into Congenital Disorders of Glycosylation

NCT04199000

The purpose of this research is to study the natural history of congenital disorders of glycosylation and its causes and treatments.

Congenital Disorders of Glycosylation

Icahn School of Medicine at Mount Sinai500 participantsStarted Oct 2019

San Diego, California, United States • Aurora, Colorado, United States • Jacksonville, Florida, United States +9 more locations

COMPLETEDPhase 1< 1 mile

A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7248824 in Participants With Angelman Syndrome (AS)

NCT04428281

This is a phase I, multicenter, non-randomized, adaptive, open-label, multiple ascending, intra-participant, dose-escalation study with a long-term extension (LTE) part and an optional open-label extension (OOE) part. The objective of the study is to investigate the safety, tolerability, PK and PD of RO7248824 administered intrathecally (IT) in participants with AS. Two linked sets of dose escalation cohorts are planned based on two different age groups, namely participants with AS aged ≥ 5 to ≤ 12 years in cohorts A1 to A5 (with at least 2 participants ≤ 8 years old in each cohort) and AS participants aged ≥ 1 to ≤ 4 years in cohorts B1 to B5. The two sets of cohorts will be run in parallel, with each cohort A1 to A5 preceding and gating the linked cohort B1 to B5 (e.g., A1 precedes B1).

Angelman Syndrome

Hoffmann-La Roche74 participantsStarted Aug 2020

Los Angeles, California, United States • San Diego, California, United States • Chicago, Illinois, United States +9 more locations

Clinical and Basic Investigations Into Congenital Disorders of Glycosylation

A Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7248824 in Participants With Angelman Syndrome (AS)

Find Trials by Condition in San Diego

Topical Ruxolitinib Evaluation in Vitiligo Study 2 (TRuE-V2)

Topical Ruxolitinib Evaluation in Vitiligo Study 1 (TRuE-V1)

A Proof-of-concept Study of the Efficacy and Safety of Nipocalimab in Participants With Active Rheumatoid Arthritis

A Phase 2 Safety and Efficacy Study of INCB050465 in Subjects With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (CITADEL-202)

Families Left Behind

ERG Components in Schizophrenia and Bipolar Disorder Type I

Study of Uterine Prolapse Procedures - Randomized Trial

ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation

Study of JK07 in Patients With Chronic Heart Failure

A Study Assessing Adverse Events and Disease Activity When Comparing Intravenously (IV) Infused ABBV-400 to Trifluridine and Tipiracil (LONSURF) Oral Tablets Plus IV Infused Bevacizumab in Adult Participants With c-Met Protein Above Cutoff Level Above Refractory Metastatic Colorectal Cancer

A Study of [225Ac]-FPI-2059 in Adult Participants With Solid Tumours

[177Lu]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer

Combination Chemotherapy, Radiation Therapy, and Bevacizumab in Treating Patients With Newly Diagnosed Stage III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

A Study to Evaluate the Effect of Ustekinumab on Cytochrome P450 Enzyme Activities Following Induction and Maintenance Dosing in Participants With Active Crohn's Disease or Ulcerative Colitis

Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year

Study of INV-102 Ophthalmic Solution in Adults With Acute Infectious Keratoconjunctivitis

Study of Safety and Effectiveness of the Boston Orthokeratology Shaping Lens in the Arise Orthokeratology Lens

An Efficacy, Safety, and Tolerability Study of VX-880 in Participants With Type 1 Diabetes With a Kidney Transplant