Clinical Trials in Portland

Showing 6541-6560 of 10,048 trials

Dose-Finding Study to Evaluate the Safety, Efficacy, & Tolerability of Multiple Doses of rAvPAL-PEG in Subjects With PKU

NCT00925054

The purpose of this study is to evaluate whether weekly injections of phenylalanine ammonia lyase (rAvPAL-PEG) can reduce blood phenylalanine concentrations in PKU subjects and whether repeated administration is safe.

Phenylketonuria

BioMarin Pharmaceutical40 participantsStarted Sep 2009

Aurora, Colorado, United States • Decatur, Georgia, United States • Chicago, Illinois, United States +8 more locations

COMPLETEDPhase 3< 1 mile

Clinical Study of Macitentan in Patients With Pulmonary Arterial Hypertension to Psychometrically Validate the PAH-SYMPACT Instrument

NCT01841762

SYMPHONY is prospective, multi-center, open-label, single-arm, Phase 3b psychometric validation study of the PAH-SYMPACT, a new quality of life questionnaire for patients with pulmonary arterial hypertension. Patients will be in the study for 5 1/2 months, 4 months of which they will receive macitentan, 10 mg, once daily. The primary objectives are to demonstrate the final content validity of the PAH SYMPACT instrument, to demonstrate the psychometric characteristics of reliability and construct validity of the PAH-SYMPACT instrument, and to demonstrate the ability of the PAH SYMPACT instrument to detect change. The secondary objective is to assess the safety of macitentan in patients with pulmonary arterial hypertension. The exploratory objective is to explore the effects of macitentan on PAH symptoms and their impact (as measured by the PAH-SYMPACT) in patients with pulmonary arterial hypertension.

Pulmonary Arterial Hypertension

Actelion284 participantsStarted Apr 2013

Birmingham, Alabama, United States • Birmingham, Alabama, United States • Phoenix, Arizona, United States +78 more locations

Dose-Finding Study to Evaluate the Safety, Efficacy, & Tolerability of Multiple Doses of rAvPAL-PEG in Subjects With PKU

Clinical Study of Macitentan in Patients With Pulmonary Arterial Hypertension to Psychometrically Validate the PAH-SYMPACT Instrument

Find Trials by Condition in Portland

LV Dysfunction Following Pacemaker Placement

Efficacy and Safety Evaluation of AN2690 Topical Solution to Treat Onychomycosis of the Toenail

Combined Antioxidant and Preeclampsia Prediction Studies (CAPPS)

Evaluate Risk/Benefit of Nab Paclitaxel in Combination With Gemcitabine and Carboplatin Compared to Gemcitabine and Carboplatin in Triple Negative Metastatic Breast Cancer (or Metastatic Triple Negative Breast Cancer)

Abatacept in the Treatment of Uveitis

Thyroid Therapy for Mild Thyroid Deficiency in Pregnancy

A Simplified Patient-Centered Educational Tool for Improved Hearing-Aid Outcomes

Patent Foramen Ovale Closure or Medical Therapy After Stroke - RESPECT Trial

Study to Evaluate Safety & Efficacy of Sarecycline in Treatment of Acne

GLobal Assessment of Plaque reGression With a PCSK9 antibOdy as Measured by intraVascular Ultrasound

A Randomized, Open-Label, Parallel-Group, Multi-Center Study for the Evaluation of Efficacy and Safety of Edoxaban Monotherapy Versus Low Molecular Weight (LMW) Heparin/Warfarin in Subjects With Symptomatic Deep-Vein Thrombosis

GSK1120212 Rollover Study

A Study to Assess the Safety of a Potential New Drug in Comparison to the Standard Practice of Dosing With Warfarin for Non-valvular Atrial Fibrillation

Detect Fluid Early From Intra-thoracic Impedance Monitoring

Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock

Study to Assess the Efficacy and Safety of PT003, PT005, and PT001 in Subjects With Moderate to Very Severe COPD

Heart Outcomes Prevention and Evaluation 4

Veterans Individual Placement and Support Towards Advancing Recovery