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Clinical Trials in North Carolina | 15,496 Studies Near You | Clareo Health

Clinical Trials LocationsNorth Carolina

Clinical Trials in North Carolina

Discover 15,496 clinical trials near North Carolina. Find research studies in your area.

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Breast Cancer Lung Cancer Prostate Cancer Colorectal Cancer Melanoma Leukemia Lymphoma Pancreatic Cancer

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Showing 10101-10120 of 15,496 trials

COMPLETEDPhase 225 miles

An Efficacy and Safety Study of LYC-30937-EC in Subjects With Moderate Chronic Plaque-type Psoriasis

NCT02872285

The objective of this Phase 2 trial is to determine the efficacy and safety of LYC-30937-EC in patients with moderate plaque-type psoriasis.

Lycera Corp.33 participantsStarted Dec 2016

Carmel, Indiana, United States • Andover, Massachusetts, United States • Fridley, Minnesota, United States +4 more locations

COMPLETEDPhase 325 miles

Efficacy and Safety of AN2690 Topical Solution to Treat Onychomycosis of the Toenail

NCT01302119

The purpose of this study is to determine whether AN2690 topical solution is a safe and effective treatment for onychomycosis of the toenail.

Onychomycosis of Toenails

Pfizer604 participantsStarted Feb 2011

Phoenix, Arizona, United States • Novato, California, United States • Oceanside, California, United States +29 more locations

Find Trials by Condition in North Carolina

Breast Cancerin North Carolina Lung Cancerin North Carolina Prostate Cancerin North Carolina Colorectal Cancerin North Carolina Melanomain North Carolina Leukemiain North Carolina Lymphomain North Carolina Pancreatic Cancerin North Carolina Ovarian Cancerin North Carolina Brain Cancerin North Carolina

Data from ClinicalTrials.govTerms

COMPLETEDPhase 238 miles

A Study of LY900010 in Erectile Dysfunction

NCT01160289

The primary purpose of the study is to compare the efficacy of LY2452473 + tadalafil to tadalafil alone in improving the erectile function (EF) of men with erectile dysfunction (ED) who incompletely respond to tadalafil alone.

Erectile Dysfunction

Eli Lilly and Company410 participantsStarted Oct 2010

Birmingham, Alabama, United States • Phoenix, Arizona, United States • Glendora, California, United States +33 more locations

COMPLETED41 miles

Collecting and Storing Biological Samples From Young Patients With Hodgkin?s Lymphoma

NCT00900250

This laboratory study is collecting and storing samples of tissue and blood from young patients with Hodgkin's lymphoma. Collecting and storing samples of tumor tissue and blood from patients with cancer to study in the laboratory may help the study of cancer in the future.

Ann Arbor Stage I Childhood Hodgkin LymphomaAnn Arbor Stage II Childhood Hodgkin LymphomaAnn Arbor Stage III Childhood Hodgkin Lymphoma+2 more

Children's Oncology Group1,271 participantsStarted Oct 2006

Birmingham, Alabama, United States • Birmingham, Alabama, United States • Phoenix, Arizona, United States +180 more locations

COMPLETEDPhase 345 miles

Extension Study of Etelcalcetide in the Treatment of Secondary Hyperparathyroidism (SHPT) in Patients With Chronic Kidney Disease (CKD) on Hemodialysis

NCT01785875

This study is designed to describe the long-term safety and efficacy of etelcalcetide (AMG 416) for the treatment of SHPT in adults with CKD on hemodialysis.

Hyperparathyroidism, Secondary

Amgen891 participantsStarted Jul 2013

Birmingham, Alabama, United States • Pine Bluff, Arkansas, United States • Azusa, California, United States +205 more locations

COMPLETEDPhase 257 miles

Evaluating Ventricular Arrhythmia in Subjects With Implantable Cardioverter Defibrillator or Cardiac Resynchronization Therapy-Defibrillator

NCT02104583

The primary objective of this study is to evaluate the effect of eleclazine (GS-6615) compared to placebo on the overall occurrence of appropriate implantable cardioverter-defibrillator (ICD) interventions (antitachycardia pacing \[ATP\] or shock) in adults with ICD or cardiac resynchronization therapy-defibrillator (CRT-D).

Ventricular Arrhythmia

Gilead Sciences313 participantsStarted Sep 2014

Mesa, Arizona, United States • Long Beach, California, United States • Los Angeles, California, United States +81 more locations

UNKNOWNNA144 miles

Clinical Study of the Sonablate® 500 to Treat Localized (T1c/T2a) Prostate Cancer

NCT00770822

This study will compare high intensity focused ultrasound to standard brachytherapy in the treatment of primary, organ confined prostate cancer.

Prostate Cancer

SonaCare Medical466 participantsStarted Apr 2007

Birmingham, Alabama, United States • Naples, Florida, United States • Myrtle Beach, South Carolina, United States +3 more locations

COMPLETEDNA183 miles

Interactive Digital Intervention to Prevent Violence Among Young Adults

NCT03820609

The primary aim of this Phase I SBIR is to create and test an alpha version of Make a Change for mobile devices, and to document the technical merit, commercial viability, and proof of concept of the product. Successful completion of this proposal will result in the creation of two assets: 1) an "Intervention Manual" that (similar to a logic model) will align key game mechanics with theory and behavior change goals and, 2) the digital application for mobile devices. Focus groups and interviews with students, as well as interviews with campus stakeholders, will be used to inform development of the digital application and ensure its commercial viability. A non-randomized open trial with a 1-month follow up will assess preliminary effects on attitudes and behaviors, and will establish procedures for assessing change in proximal (attitude) and distal (behavioral) outcomes in preparation for large-scale evaluation in a Phase 2 SBIR proposal. This line of research and development has the potential to develop a commercially viable product with high public health impact that can be disseminated to 1700+ community colleges and 3,000+ 4-year colleges, and readily adapted to high schools, clinics and military settings.

Happy People Games, LLC41 participantsStarted Jun 2018

Warwick, Rhode Island, United States • Clemson, South Carolina, United States

TERMINATEDNA186 miles

Evaluation of Cardiac Compass With OptiVol in the Early Detection of Decompensation Events for Heart Failure

NCT00510198

The purpose of the PRECEDE-HF study is to collect data to compare patients whose heart failure is managed using Cardiac Compass with OptiVol (which is a tool in the device that records information about the heart that doctors can use to help treat their heart disease) combined with standard treatment methods (Access Group) to patients whose heart failure is managed by standard treatment methods only (Control Group). This comparison will show if the additional monitoring provided by Cardiac Compass with OptiVol delays the time patients are first admitted to hospital for heart failure or delays the time to death.

Congestive Heart Failure

Medtronic Cardiac Rhythm and Heart Failure120 participantsStarted Oct 2007

Anchorage, Alaska, United States • Little Rock, Arkansas, United States • Berkeley, California, United States +30 more locations

TERMINATEDPhase 1197 miles

Safety, Tolerability and Pharmacokinetics of Multiple Rising Doses of Ixazomib in Lupus Nephritis (LN)

NCT02176486

The purpose of this study is to characterize the safety and tolerability of ixazomib when administered as multiple oral doses at escalating dose levels in participants with lupus nephritis.

Lupus Nephritis

Takeda12 participantsStarted Jun 2014

La Jolla, California, United States • Upland, California, United States • Port Charlotte, Florida, United States +32 more locations

COMPLETEDPhase 3232 miles

Safety And Efficacy of Sofosbuvir/Velpatasvir/Voxilaprevir Fixed-Dose Combination for 12 Weeks in Adults Who Participated in a Prior Gilead-Sponsored HCV Treatment Study

NCT03118843

The primary objectives of this study are to determine the efficacy, safety, and tolerability of treatment with sofosbuvir/velpatasvir/voxilaprevir (SOF/VEL/VOX) fixed-dose combination (FDC) for 12 weeks in participants with chronic hepatitis C virus (HCV) infection with or without cirrhosis, who did not achieve sustained viral response (SVR) after receiving prior treatment in a Gilead-sponsored HCV treatment study of direct-acting antiviral (DAA)-containing regimens.

Hepatitis C Virus Infection

Gilead Sciences31 participantsStarted Apr 2017

Los Angeles, California, United States • Los Angeles, California, United States • Palo Alto, California, United States +24 more locations

COMPLETEDPhase 2267 miles

Selonsertib in Adults With Pulmonary Arterial Hypertension

NCT02234141

The primary objective of this study is to evaluate the effect of selonsertib (GS-4997) on pulmonary vascular resistance (PVR), as measured by right heart catheterization (RHC) in adults with pulmonary arterial hypertension (PAH). The study will consist of a 24-week placebo-controlled treatment period and a long-term selonsertib treatment period. Participants completing the 24-week placebo-controlled period will be eligible to receive active treatment with selonsertib in the long-term treatment period.

Pulmonary Arterial Hypertension

Gilead Sciences151 participantsStarted Nov 2014

Mobile, Alabama, United States • Phoenix, Arizona, United States • Phoenix, Arizona, United States +43 more locations

UNKNOWNNA272 miles

A Multicenter Clinical Study of the Sonablate®450 for the TreAtment of Locally Recurrent Prostate Cancer With HIFU (STAR Trial)

NCT00772317

For the treatment of locally recurrent prostate cancer following failed external beam radiation therapy (EBRT)

Recurrent Prostate Cancer

SonaCare Medical117 participantsStarted Jul 2008

Los Angeles, California, United States • Los Angeles, California, United States • Washington D.C., District of Columbia, United States +13 more locations

TERMINATEDPhase 2275 miles

Evaluation of CRS-207 With Pembrolizumab in Previously Treated Malignant Pleural Mesothelioma (MPM)

NCT03175172

The purpose of this study is to evaluate whether CRS-207 with pembrolizumab is safe and effective in adults with MPM who have failed prior anti-cancer therapy.

Malignant Pleural Mesothelioma

Aduro Biotech, Inc.10 participantsStarted May 2017

San Francisco, California, United States • Tampa, Florida, United States • Chicago, Illinois, United States +5 more locations

UNKNOWNNA291 miles

Frequency of Screening and SBT Technique Trial

NCT02399267

The requirement for invasive mechanical ventilation is a defining feature of critical illness. Liberation or weaning is the process during which the work of breathing is transferred from the ventilator back to the patient. Approximately 40% of the time spent on mechanical ventilation is dedicated to weaning. Limiting the duration of invasive ventilation has been identified as a key research priority in critical care. Studies support the use of screening protocols (once daily vs. usual care) to identify weaning candidates and the conduct of tests of patient's ability to breathe spontaneously (SBTs). While once daily screening is the current standard of care in national intensive care units (ICUs), it is poorly aligned with the 24/7 ICU care environment wherein a critically ill patients' status can change from hour to hour. Only one large trial has compared alternative SBT techniques \[T-piece vs PS (Pressure Support)\]. No trial has compared a strategy of more frequent screening to once daily screening or alternative SBT techniques. The presence of respiratory therapists (RTs) 24/7 in North American ICUs presents a unique opportunity to screen more frequently, conduct more frequent SBTs, and determine the optimal strategy to liberate critically ill adults from invasive ventilation. The investigators propose to conduct a pilot randomized trial in 100 critically ill adults comparing 'once daily' screening to 'at least twice daily' screening and PS vs. T-piece SBTs in 12 Canadian ICUs. In the proposed trial, the investigators will (i) assess their ability to recruit critically ill adults who can breathe spontaneously or initiate breaths on one of several commonly used modes of ventilation into the trial, (ii) evaluate clinician's ability to implement the trial as designed, (iii) assess current practices in sedation, analgesia and delirium management and timing of patient mobilization prior to conducting screening assessments, (iv) identify barriers (clinician, institutional) to enrolling patients, (v) characterize trial participants based on weaning difficulty, and (vi) obtain preliminary estimates of the impact of the alternative screening and SBT strategies on clinically important outcomes.

Unity Health Toronto100 participantsStarted Jul 2016

Long Beach, California, United States • Atlanta, Georgia, United States • Vancouver, British Columbia, Canada +7 more locations

COMPLETEDNA305 miles

Development and Feasibility Testing of a Lung Cancer Screening Decision Aid

NCT02790866

This study evaluates the feasibility and acceptability of LuCaS Choices, a web-based decision aid designed to facilitate informed decision making about participation in lung cancer screening among individuals at high risk of lung cancer due to heavy cigarette smoking.

Jamie Studts50 participantsStarted Mar 2016

Miami, Florida, United States • Lexington, Kentucky, United States

COMPLETEDPhase 2308 miles

Intraprostatic PRX302 Injection to Treat Localised Prostate Cancer

NCT03081481

The purpose of this study is to determine a safe, effective, and tolerable dose of PRX302 for the treatment of low to intermediate risk prostate cancer.

Prostate Cancer

Sophiris Bio Corp38 participantsStarted Jun 2017

Ocala, Florida, United States • Baltimore, Maryland, United States • New York, New York, United States +5 more locations

COMPLETEDPhase 4620 miles

Comparability and Standardization of Controlled Allergen Challenge Facilities

NCT02543346

Allergen challenge facilities have been utilized for many years in clinical drug trials studying onset of action, proof of concept, duration of action, and efficacy. Each facility has somewhat different design characteristics and pollen dispersal technologies. Facilities are located in disparate geographic areas and have populations of participants who are sensitized to allergens unique to that area. Therefore, facilities have operated as single sites with little effort to evaluate facility comparability or to attempt standardization across facilities. The purpose of this study is to compare the two sites and assess whether the sites are able to achieve similar symptom scores.

Allergic Rhinitis

Queen's University98 participantsStarted Oct 2015

San Antonio, Texas, United States • Kingston, Ontario, Canada

UNKNOWNNA756 miles

Seeing-Moving-Playing: Early Rehabilitation Utilizing Visual and Vestibular Technology Following Traumatic Brain Injury

NCT03215082

The aim of this research program is to 1) Evaluate potential problems with vision, inner ear-eye reflexes and deficits of processing eye information that occur following TBI; and 2) Evaluate treatment programs for individuals with eye and inner ear problems that persist for greater than 10 days following injury. This study will include 465 youth and young adults (aged 6-30 years old) who sustain a TBI of any severity. An initial evaluative phase using the best available technology to evaluate eye and inner ear function will be performed, and compared with typical tests that are used in the clinic. If symptoms and functional problems remain 10 days after injury, participants will be randomly placed into a treatment group (including eye movement, inner ear-eye reflex and attention exercises as per our pilot studies) or a control group (typical rehabilitation). Success will be measured in terms of return to sport (mild TBI), achievement of goals (moderate and severe TBI) and quality of life. It is expected that this program will inform clinical practice and future research leading to a treatment program in TBI that includes multiple components.

Mild Traumatic Brain Injury; Concussion

McGill University Health Centre/Research Institute of the McGill University Health Centre400 participantsStarted Jan 2018

Calgary, Alberta, Canada • Montreal, Quebec, Canada • Saint-Maurice, France +1 more locations

UNKNOWNNA1571 miles

Efficacy and Effectiveness of a Self-applied Online Program to Promote Resilience and Coping Skills in College Students

NCT03903978

This study aims to evaluate the effectiveness and efficiency of this intervention protocol applied to three populations of Spanish-speaking university students (Spain, Argentina and Mexico). The purpose of this paper is to present the protocol designed to carry out the randomised controlled study (RCT).

CORE ConditionHealthy Lifestyle Psychoeducational ProgramWaiting List Control

Universitat Jaume I324 participantsStarted Nov 2018

Mar del Plata, Buenos Aires, Argentina • Buenos Aires, Argentina • Pachuca, Hidalgo, Mexico +2 more locations

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