Clinical Trials in North Carolina

Showing 2761-2780 of 20,428 trials

Assessing Chest Pain Using Point-of-Care High-Sensitivity Troponin I in the Emergency Department

NCT06899776

The goal of this proposal is to improve the quality and value of care for patients with acute chest pain by investigating the potential impact of point-of-care (POC) high sensitivity cardiac troponin (hs-cTn) testing in the Emergency Department (ED) and exploring how best to integrate POC hs-cTnl into ED risk stratification workflows. The study hypothesizes that the Abbott i-STAT POC hs-cTnI assay will decrease time-to-result (TTR) and ED length of stay (LOS), while increasing ED revenue for patients with acute chest pain compared to a strategy of central laboratory hs-cTnI testing.

ACS (Acute Coronary Syndrome)

Wake Forest University Health Sciences600 participantsStarted Feb 2025

Charlotte, North Carolina, United States • High Point, North Carolina, United States • Winston-Salem, North Carolina, United States

RECRUITING41 miles

Brain Structure and Clinical Endpoints in Myotonic Dystrophy Type 2

NCT05854433

Nearly two-third of patients with myotonic dystrophy type 2 (DM2) report that impaired cognition is among the most disabling symptoms and deeply affects their quality of life. Yet, relatively little is known about how DM2 affects brain structure and cognitive function as brain imaging studies in DM2 are extremely limited. This is a prospective, cross-sectional study of brain structure and function on cognitive and motor performance in patients with DM2 \& DM1 compared to healthy controls. All participants will undergo magnetic resonance imaging (MRI) to evaluate brain structure and white matter integrity, a comprehensive battery of cognitive and motor measures, self-reported questionnaires, and blood collection for brain-based biomarker analysis. A subset of participants will undergo lumbar puncture for cerebrospinal fluid (CSF) collection for additional biomarker analysis and validation. This work is critical to inform the development of rigorous clinical trial designs and plan for a longitudinal study to evaluate MRI measures as imaging biomarkers of disease progression and therapeutic response in DM2 \& DM1.

Myotonic Dystrophy Type 2Myotonic Dystrophy Type 1

Wake Forest University Health Sciences100 participantsStarted Apr 2023

Winston-Salem, North Carolina, United States

Assessing Chest Pain Using Point-of-Care High-Sensitivity Troponin I in the Emergency Department

Brain Structure and Clinical Endpoints in Myotonic Dystrophy Type 2

Find Trials by Condition in North Carolina

PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation

Phase 3 Study on the Efficacy and Safety of Human Plasma Derived Antithrombin (Atenativ) in Heparin-Resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass

Toxicity Genetic Determinants and Response to Azacitidine and Venetoclax in AML

Comparison of Two- Versus Three-antibiotic Therapy for Pulmonary Mycobacterium Avium Complex Disease

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients Receiving the Usual Chemotherapy Treatment for Bladder Cancer, ARCHER Study

A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia

Evaluation of Enhanced Lithotripsy System (ELS) in the Treatment of Urinary Stones, A Pivotal Trial

Phase 3 Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Placebo in Adults With Symptomatic nHCM

Phase 2 Study to Evaluate Safety and Efficacy of Cretostimogene Grenadenorepvec in High-Risk NMIBC

Study of Axicabtagene Ciloleucel Given With Steroids In Participants With Relapsed Or Refractory Large B-Cell Lymphoma

A Weight Loss Study Evaluating Subcutaneous Treatment With AZD9550 and AZD6234 in Combination Against Placebo or Each of the Drugs Alone

Montalcino Aortic Consortium: Precision Medicine for Heritable Thoracic Aortic Disease

Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3

Phase 3 Randomized, Modified Double-blind, Active-controlled Safety Study on vYF in Adults

Open-label Extension Study to Evaluate Metreleptin in Patients With Partial Lipodystrophy

A Study of PRT3789 in Combination With Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors With a SMARCA4 Mutation

The Effect of Kinisoquin™ on Thromboembolic Events in Patients With Metastatic or Locally Advanced Pancreatic Cancer

Gene Transfer Study in Patients With Late Onset Pompe Disease