Clinical Trials in New York

Showing 6281-6300 of 17,259 trials

Study of Droxidopa Treatment in Adults With Attention Deficit Hyperactivity Disorder With Co-administration of Carbidopa

NCT00983814

Attention Deficit Hyperactivity Disorder (ADHD) is a neurobiological disorder characterized by lifelong issues of inattention, distraction, organizational difficulties, forgetfulness, restlessness, talking out of turn, difficulty waiting and interrupting others. ADHD is the second most common neuropsychiatric disorder affecting 4.4% of the United States (US) adult population, or between 8-9 million individuals. Droxidopa (L-dihydroxyphenylserine (L-DOPS)) is a synthetic catecholamine which is converted to norepinephrine (NE) via decarboxylation, resulting in increased levels of NE centrally in the central nervous system (CNS) and peripherally. Co-treatment with carboxylase inhibitors, such as carbidopa, given with droxidopa, can increase the CNS levels of NE with greater crossing of the blood-brain barrier. Droxidopa has received orphan drug approval by the Food and Drug Administration (FDA) for the treatment of symptomatic neurogenic orthostatic hypotension in individuals with primary autonomic failure. The half-life of droxidopa is approximately 2-3 hours, resulting in administration three times daily.

Attention Deficit Hyperactivity Disorder

Chelsea Therapeutics20 participantsStarted Oct 2009

New York, New York, United States

UNKNOWNNA< 1 mile

DuraSorb® in Prosthetic Breast Reconstruction

NCT04646057

This study compares outcomes of prospective mesh-based breast reconstructions to historical control breast reconstructions with no mesh.

Breast Reconstruction

Surgical Innovation Associates, Inc.168 participantsStarted Jan 2021

Chicago, Illinois, United States • Chicago, Illinois, United States • Evanston, Illinois, United States +4 more locations

Study of Droxidopa Treatment in Adults With Attention Deficit Hyperactivity Disorder With Co-administration of Carbidopa

DuraSorb® in Prosthetic Breast Reconstruction

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Study To Evaluate The Efficacy And Safety Of Balovaptan In Adults With Post-Traumatic Stress Disorder (PTSD)

A Study to Evaluate the Efficacy and Safety of Recombinant Human Pentraxin-2 (rhPTX-2; PRM-151) in Participants With Idiopathic Pulmonary Fibrosis

Study of Efficacy and Safety of CTL019 in Adult DLBCL Patients

The Effects of a Home-Based Fall Prevention Program on Community-Dwelling Elderly's Fall Risk Category

Study of Turning Point Therapeutics LM-302 in Patients With Advance Solid Tumors

A Study to Evaluate the Efficacy, Safety, and Tolerability of SAGE-324 in Participants With Essential Tremor

An Exploratory Study Examining Biopsychosocial Markers of Anxiety and Depression

Phase 0 Master Protocol for CIVO Intratumoral Microdosing of Anti-Cancer Therapies

Analyzing Childhood Recall Antigens in Patients With Pancreatic Cancer

Skin Irritation Potential of MOB015B in Healthy Subjects Using a Cumulative Irritant Patch Test Design

OCT Evaluation of Neurotrophic Ulcer Following Treatment With Oxervate

Penetration-enhanced Direct DBD Non-thermal Plasma for Hair Loss

Evaluation of Dalteparin for Long-term (One Year) Treatment of Blood Clots in Subjects With Cancer

Safety and Immunogenicity of Pneumococcal Conjugate Formulations in Healthy Adults 18 Through 49 Years of Age

A Study to Evaluate the Effect of Dupilumab on Exercise Capacity in Adult Patients With Asthma

Prospective Multicenter Evaluation of a New Predictive Model for the Progression of Adolescent Idiopathic Scoliosis

OPTIMISE-CKD Drug Utilization

Epigenetics, Vitamin C, and Abnormal Blood Cell Formation - Vitamin C in Patients With Low-Risk Myeloid Malignancies