Clinical Trials in New York

Showing 5781-5800 of 17,259 trials

Phase 1, First-in-human Study of Oral TP-1287 in Patients with Advanced Solid Tumors

NCT03604783

TP-1287 is an oral phosphate prodrug of the CDK9 inhibitor, alvocidib. This is a Phase 1, open-label, dose-escalation, dose-expansion, safety, pharmacokinetics, and pharmacodynamic study, with a purpose of determining the maximum tolerated dose (MTD) and dose-limiting toxicities (DLTs) of oral TP-1287 in patients with advanced metastatic or progressive solid tumors who are refractory to, or intolerant of, established therapy known to provide clinical benefit for their condition.

Advanced Solid TumorsSarcomaEwing Sarcoma+2 more

Sumitomo Pharma America, Inc.74 participantsStarted Dec 2018

Los Angeles, California, United States • Miami, Florida, United States • Boston, Massachusetts, United States +7 more locations

Active Not RecruitingNA< 1 mile

Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM

NCT03630289

This study assesses the safety of using tissue autograft of a pedicled temporoparietal fascial (TPF) or pericranial flap into the resection cavity of newly diagnosed glioblastoma multiforme (GBM) patients. The objective of the study is to demonstrate that this surgical technique is safe in a small human cohort of patients with resected newly diagnosed GBM and may improve progression-free survival (PFS).

GlioblastomaGlioblastoma MultiformeGBM+1 more

Northwell Health12 participantsStarted Jul 2018

New York, New York, United States

Phase 1, First-in-human Study of Oral TP-1287 in Patients with Advanced Solid Tumors

Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM

Find Trials by Condition in New York

Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Children, Known or Suspected to be Caused by Susceptible Gram-positive Organisms, Including MRSA

Sleep, Exercise, Nutrition and Survivorship in Prostate Cancer

Zenith® p-Branch® and Zenith® Fenestrated AAA Endovascular Graft Clinical Study

A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (MK-7962-003/A011-11)(STELLAR)

Study to Evaluate Safety, Tolerability, PK and PD of DCR-PHXC in PH Type 3 Patients

Risk Stratification and Early Alerting Regarding COVID-19 Hospitalization

Study to Evaluate Treatment Compliance, Efficacy and Safety of an Improved Deferasirox Formulation (Granules) in Pediatric Patients (2-<18 Years Old) With Iron Overload

Study to Evaluate Safety, Tolerability and Efficacy of Saroglitazar Mg in Patients With Primary Biliary Cholangitis

Peer Mentorship to Improve Outcomes in Patients on Maintenance Hemodialysis

AI ENRICH - AI Detection of ICH

Comparing Olanzapine and Mirtazapine in the Improvement of Unintentional Weight Loss for Patients with Advanced Stage Cancer

Study of Safety and Pharmacokinetics of Oral Doses of EPX-100 in Healthy Subjects.

A Safety and Efficacy Study in Patients With Gastric Cancer

Long-term Safety of Lumacaftor/Ivacaftor in Participants With Cystic Fibrosis Who Are Homozygous for F508del and 12 to <24 Months of Age at Treatment Initiation

An Open-Label Extension Study for Patients With Duchenne Muscular Dystrophy Who Participated in Studies of SRP-5051 (Vesleteplirsen)

Strategies to Assist With Management of Pain

Study of AZD9291 Plus MEDI4736 Versus AZD9291 Monotherapy in NSCLC After Previous EGFR TKI Therapy in T790M Mutation Positive Tumours

A Phase I/II Trial Investigating LOAd703 in Combination With Atezolizumab in Malignant Melanoma