Clinical Trials in New York

Showing 3441-3460 of 17,259 trials

Anti-viral Therapy in Alzheimer's Disease

NCT03282916

Anti-viral therapy in Alzheimer's disease will investigate the efficacy of treating patients with mild Alzheimer's disease with the U.S.A marketed generic anti-viral drug Valtrex (valacyclovir, 500mg oral tablet). Valacyclovir, titrated to 4 grams per day, repurposed to treat Alzheimer's disease, will be compared to matching placebo in the treatment of 130 mild AD patients (65 valacyclovir, 65 placebo) who test positive for herpes simplex virus-1 (HSV1) or herpes simplex virus-2 (HSV2). The study will be a randomized, double-blind, 18-month Phase II proof of concept trial.

Alzheimer DiseaseHerpes Simplex 1Herpes Simplex 2

Columbia University120 participantsStarted Feb 2018

Phoenix, Arizona, United States • New York, New York, United States • New York, New York, United States

COMPLETEDPhase 2< 1 mile

Study to Evaluate Safety and Efficacy of VX-661 in Combination With Ivacaftor in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation With an Open-Label Expansion

NCT02070744

The objective of this study was to evaluate the safety and efficacy of VX-661in combination with ivacaftor in participants with cystic fibrosis (CF) who are homozygous for F508del cystic fibrosis transmembrane conductance regulator (CFTR) mutation

Cystic Fibrosis

Vertex Pharmaceuticals Incorporated40 participantsStarted Mar 2014

Birmingham, Alabama, United States • Palo Alto, California, United States • Stanford, California, United States +20 more locations

Anti-viral Therapy in Alzheimer's Disease

Study to Evaluate Safety and Efficacy of VX-661 in Combination With Ivacaftor in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation With an Open-Label Expansion

Find Trials by Condition in New York

A Study to Evaluate the Efficacy and Safety of BLI5100 in Patients With Erosive Esophagitis

Metabolic Mechanisms Induced by Enteral DHA and ARA Supplementation in Preterm Infants

A Study Testing the Use of a Perivascular Sirolimus Formulation (Sirogen) in ESRD Patients Undergoing AV Fistula Surgery

A Clinical Study of Intismeran Autogene (V940) Plus Pembrolizumab in People With High-Risk Melanoma (V940-001)

Phase 2a Study of VX-147 in Adults With APOL1-mediated Focal Segmental Glomerulosclerosis

Daily Vitamin D for Sickle-cell Respiratory Complications

A Study of BH-30236 in Relapsed/ Refractory Acute Myelogenous Leukemia and Higher Risk Myelodysplastic Syndrome

Single-Sided Deafness and Asymmetric Hearing Loss

A Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy

Adherence Connection for Counseling, Education, and Support (ACCESS) II

Brentuximab Vedotin and Nivolumab for the Treatment of Patients With Relapsed/Refractory Classical Hodgkin Lymphoma

Reducing Burden in Care Partners of Community-Dwelling Persons With Dementia and Oropharyngeal Dysphagia

Comparing Hypothermic Temperatures During Hemiarch Surgery

A Study of AZD3427 in Participants With Heart Failure and Pulmonary Hypertension Group 2

A Clinical Trial on Safety and Efficacy of CBT-001 in Patients With Pterygium

A Dose Escalation Study of SHP2 Inhibitor in Patients With Solid Tumors Harboring KRAS of EGFR Mutations

A Study to Evaluate ELX/TEZ/IVA on Cough and Physical Activity in Participants With Cystic Fibrosis (CF)

Phase1/2a Study for IPG7236 in Patients With Advanced Solid Tumors