Clinical Trials in New York State

Showing 3141-3160 of 14,718 trials

Comparing Hypothermic Temperatures During Hemiarch Surgery

NCT02860364

Hypothermic circulatory arrest is an important surgical technique, allowing complex aortic surgeries to be performed safely. Hypothermic circulatory arrest provides protection to cerebral and visceral organs, but may result in longer cardiopulmonary bypass times during surgery, increased risks of bleeding, inflammation, and neuronal injury. To manage these consequences, a trend towards warmer core body temperatures during circulatory arrest has emerged. This trial will randomize patients to either mild (32°C) or moderate (26°C) hypothermia during aortic hemiarch surgery to determine if mild hypothermia reduces the length of cardiopulmonary bypass time and other key measures of morbidity and mortality.

Thoracic Aortic Disease

Ottawa Heart Institute Research Corporation282 participantsStarted Feb 2018

Boston, Massachusetts, United States • Ridgewood, New Jersey, United States • Columbus, Ohio, United States +9 more locations

Active Not RecruitingPhase 398 miles

A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy

NCT03690388

The objective of this study is to evaluate the effect of cabozantinib compared with placebo on progression free survival (PFS) and objective response rate (ORR) in subjects with Radioiodine-Refractory Differentiated Thyroid Cancer (DTC) who have progressed after prior vascular endothelial growth factor receptor (VEGFR)-Targeted therapy.

Differentiated Thyroid Cancer

Exelixis187 participantsStarted Oct 2018

Newport Beach, California, United States • Sacramento, California, United States • San Francisco, California, United States +161 more locations

Comparing Hypothermic Temperatures During Hemiarch Surgery

A Study of Cabozantinib Compared With Placebo in Subjects With Radioiodine-refractory Differentiated Thyroid Cancer Who Have Progressed After Prior Vascular Endothelial Growth Factor Receptor (VEGFR) -Targeted Therapy

Find Trials by Condition in New York State

Brentuximab Vedotin and Nivolumab for the Treatment of Patients With Relapsed/Refractory Classical Hodgkin Lymphoma

Zanubrutinib, Obinutuzumab, and Sonrotoclax in Previously Untreated Patients With CLL or SLL

Study of OCA in Combination With BZF Evaluating Efficacy, Safety and Tolerability in Participants With PBC

Phase 2a Study of VX-147 in Adults With APOL1-mediated Focal Segmental Glomerulosclerosis

Metabolic Mechanisms Induced by Enteral DHA and ARA Supplementation in Preterm Infants

Study to Evaluate Safety and Efficacy of VX-661 in Combination With Ivacaftor in Subjects With Cystic Fibrosis, Homozygous for the F508del-CFTR Mutation With an Open-Label Expansion

Single-Sided Deafness and Asymmetric Hearing Loss

ENCALM: A Study of ENX-102 as a Monotherapy Treatment in Patients With Generalized Anxiety Disorder

Phase 1 Study Evaluating BA3182 in Patients With Advanced Adenocarcinoma.

An Observational Registry of Abatacept in Patients With Juvenile Idiopathic Arthritis

Bemcentinib (BGB324) in Combination With Pembrolizumab in Patients With Advanced Non-small Cell Lung Cancer (NSCLC)

Beta-Agonist Versus OnabotulinumtoxinA Trial for Urgency Urinary Incontinence

Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients

Nitric Oxide Nasal Spray (NONS) as Prevention for Treatment of Individuals at Risk of Exposure to COVID-19 Infection

Prospective Evaluation of Breast-Conserving Surgery Alone in Low-Risk Ductal Carcinoma in Situ (DCIS)

A Clinical Trial on Safety and Efficacy of CBT-001 in Patients With Pterygium

To Assess the Pharmacokinetics and Safety and Tolerability of Efanesoctocog Alfa (BIVV001)in Adults With Type 2N and 3 Von Willebrand Disease (VWD)

A Study to Evaluate Safety and Efficacy of Empasiprubart in Adults With Dermatomyositis