Clinical Trials in Minneapolis

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Low Intensity Blood Flow Restriction Training Study

NCT03055260

The particpant will complete baseline testing by measuring subjects' quadriceps muscle thickness (cm) via ultrasound technology, as well as have them complete a one repetition maximum (1RM) test on the leg press machine and an isometric knee extension using a dynamometer - strength measures will be calculated for both right and left legs. After baseline testing, subjects will complete 6 weeks of the testing protocol that will consist of leg press exercises at 30% of their 1RM. Subjects will be randomized to either wear a cuff that partially restricts blood flow to the limb (Study Group), or to wear a cuff that does not restrict blood flow (Control Group). Exercises will be completed 2x/week and will take approximately 10 total minutes (5 for warm up, 5 for testing protocol) per session. After 6 weeks, muscle thickness, leg press 1RM, and quadriceps extension strength will be re-tested and compared to the initial measurements.

Muscle Mass

University of Minnesota8 participantsStarted May 2017

Minneapolis, Minnesota, United States

COMPLETEDPhase 2/3< 1 mile

Stem Cell Transplant for Hemoglobinopathy

NCT00176852

This study tests the clinical outcomes of one of two preparative regimens (determined by available donor source) in patients with non-malignant hemoglobinopathies. The researchers hypothesize that these regimens will have a positive effect on post transplant engraftment and the incidence of graft-versus-host-disease. Regimen A2 has replaced Regimen A in this study. Two patients were treated on Regimen A but did not have evidence of initial engraftment thus triggering the stopping rule for that arm of this study.

Sickle Cell DiseaseThalassemiaSevere Congenital Neutropenia+2 more

Masonic Cancer Center, University of Minnesota22 participantsStarted Jun 2002

Minneapolis, Minnesota, United States

Low Intensity Blood Flow Restriction Training Study

Stem Cell Transplant for Hemoglobinopathy

Find Trials by Condition in Minneapolis

Study Assessing PTI-428 Safety, Tolerability, Pharmacokinetics and Effect in Subjects With Cystic Fibrosis

Traumatic Nightmares Treated by NightWare (To Arouse Not Awaken)

Multi-Center, Randomized, Open-Label Study of G/P +/- RBV for NS5A + SOF Previously Treated GT1 HCV Subjects

PK/PD Study of U-500 Regular Insulin

Prostate Cancer Intervention Versus Observation Trial (PIVOT)

Comparison of 188-0551 Spray Versus Vehicle Spray in Subjects With Plaque Psoriasis (307)

An Investigational Study to Evaluate Experimental Medication BMS-986224 in Renally Impaired Participants

Evaluate ALLN-177 in Patients With Enteric Hyperoxaluria

The Blood Pressure and Metabolic Effects of Nebivolol in Hypertensive Patients With Impaired Glucose Tolerance or Impaired Fasting Glucose

A Study to Evaluate Tolerability and Participants Preference Between Mirabegron and Tolterodine Extended Release (ER) in Participants With Overactive Bladder (OAB)

Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Insulin

A Multiple Ascending Dose Study of MEDI7247 in Patients With Selected Relapsed/Refractory Hematological Malignancies

Telerehabilitation in the Home Versus Therapy In-Clinic for Patients With Stroke

ANG1005 in Patients With Recurrent High-Grade Glioma

Correlation Between Coronary and Carotid Atherosclerotic Disease (CAD) and Links With Clinical Outcomes

Study Testing Radium-223 Dichloride in Relapsed Multiple Myeloma

Phase 2 Clinical Trial of SGS-742 Therapy in Succinic Semialdehyde Dehydrogenase Deficiency

Study of Safety and Efficacy of BCL201 and Idelalisib in Patients With FL and MCL