Clinical Trials in Minneapolis

Showing 5841-5860 of 11,007 trials

Effects of Change in Insulin Resistance and Systemic Inflammation on Brain Structure and Function

NCT03215888

Obesity is associated with alterations in brain structure and cognitive impairment and is a risk factor for Alzheimer's disease and vascular dementia. The mechanisms underlying obesity related decline in cognitive function are not fully understood. The long-term goal of this project is to understand how obesity affects cognitive function, with the aim to develop new ways to prevent and treat obesity related cognitive decline

ObesityBariatric Surgery Candidate

University of Minnesota29 participantsStarted Nov 2017

Minneapolis, Minnesota, United States

COMPLETEDPhase 3< 1 mile

A Phase 3 Study of VX-445 Combination Therapy in Cystic Fibrosis (CF) Subjects Heterozygous for F508del and a Gating or Residual Function Mutation (F/G and F/RF Genotypes)

NCT04058353

This study will evaluate the efficacy, safety and pharmacodynamics of elexacaftor (ELX, VX-445) in triple combination (TC) with tezacaftor (TEZ) and ivacaftor (IVA) in subjects with cystic fibrosis (CF) who are heterozygous for F508del and a gating or residual function mutation (F/G and F/RF genotypes).

Cystic Fibrosis

Vertex Pharmaceuticals Incorporated271 participantsStarted Aug 2019

Birmingham, Alabama, United States • Tucson, Arizona, United States • Long Beach, California, United States +90 more locations

Effects of Change in Insulin Resistance and Systemic Inflammation on Brain Structure and Function

A Phase 3 Study of VX-445 Combination Therapy in Cystic Fibrosis (CF) Subjects Heterozygous for F508del and a Gating or Residual Function Mutation (F/G and F/RF Genotypes)

Find Trials by Condition in Minneapolis

Risankizumab Versus Secukinumab for Participants With Moderate to Severe Plaque Psoriasis

A Safety and Efficacy Trial of Multiple Dosing Regimens of ABT-719 for the Prevention of Acute Kidney Injury in Subjects Undergoing High Risk Cardiac Surgery

Obeticholic Acid (OCA) in Primary Sclerosing Cholangitis (PSC)

A Study to Evaluate the Safety and Efficacy of Tocilizumab in Patients With Severe COVID-19 Pneumonia

A Study of Oral AMN107 in Adults With Chronic Myelogenous Leukemia (CML) or Other Hematologic Malignancies

A Study of Elotuzumab in Combination With Pomalidomide and Low Dose Dexamethasone and Elotuzumab in Combination With Nivolumab in Patients With Multiple Myeloma Relapsed or Refractory to Prior Treatment With Lenalidomide.

Intercostal Nerve Block With Liposome Bupivacaine in Subjects Undergoing Posterolateral Thoracotomy

The Role of Bacteria and Genetic Variations in Cystic Fibrosis

Evaluation of Safety and Efficacy of Lumason/SonoVue in Subjects Undergoing Pharmacologic Stress BR1-142

SPIRIT 2: Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain

Safety and Efficacy Study of Sotagliflozin on Glucose Control in Participants With Type 2 Diabetes, Moderate Impairment of Kidney Function, and Inadequate Blood Sugar Control

SAR650984, Pomalidomide and Dexamethasone in Combination in RRMM Patients

A Study to Evaluate ABT-126 for the Treatment of Cognitive Deficits in Schizophrenia

SPIRIT 1: Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain

Observational Study Evaluating Long-term Health Outcomes of Canadian DUODOPA-treated Patients

Multicenter Study Of CPX-1 (Irinotecan HCl: Floxuridine) Liposome Injection In Patients With Advanced Colorectal Cancer

A Study of AK-01 (LY3295668) in Solid Tumors

Long Term Study of Canakinumab (ACZ885) in Patients With Gout