Clinical Trials in Miami

Showing 6001-6020 of 11,431 trials

SI-613 Study for Knee Osteoarthritis

NCT03209362

The objective of the study is to evaluate the efficacy and safety of intra-articular injections of SI-613 compared with placebo for knee OA.

Osteoarthritis, Knee

Seikagaku Corporation80 participantsStarted Oct 2017

Tucson, Arizona, United States • Miami, Florida, United States • Miami, Florida, United States +7 more locations

COMPLETEDPhase 1< 1 mile

A Phase I Concentration-Targeted Multidose Study of Atevirdine Mesylate ( U-87201E ), AZT, and ddI or ddC

NCT00000753

To determine the safety, toxicity, pharmacokinetic profile, and antiretroviral activity of atevirdine mesylate ( U-87201E ) in HIV-infected patients. Per 06/04/93 amendment, to also evaluate the interactive effects of didanosine ( ddI ) or zalcitabine ( dideoxycytidine; ddC ) with zidovudine ( AZT ) on the pharmacokinetics of U-87201E and to assess the effects of the triple combination therapies on immunologic and virologic parameters. Since the use of non-nucleoside reverse transcriptase inhibitors such as U-87201E has been associated with the rapid development of resistant HIV isolates, an initial evaluation of this drug in patients was made in combination with AZT. Because of the inability to detect resistance after 6 weeks of combined AZT/U-87201E therapy, this protocol will initially investigate U-87201E administered alone and then investigate the effect of this drug with AZT and ddI or ddC.

HIV Infections

National Institute of Allergy and Infectious Diseases (NIAID)30 participants

Los Angeles, California, United States • Miami, Florida, United States • St Louis, Missouri, United States +3 more locations

SI-613 Study for Knee Osteoarthritis

A Phase I Concentration-Targeted Multidose Study of Atevirdine Mesylate ( U-87201E ), AZT, and ddI or ddC

Find Trials by Condition in Miami

Effectiveness of Palifermin in Increasing CD4 Counts in Treatment-Experienced HIV Infected Adults

Tisotumab Vedotin Continued Treatment in Patients With Solid Tumors.

A Randomized, Comparative Trial of Zidovudine (AZT) Versus 2',3'-Didehydro-3'-Deoxythymidine (Stavudine; d4T) in Children With HIV Infection

The Effectiveness of Three Drug Combinations in HIV-Infected Patients Who Have Taken Zidovudine for More Than 12 Weeks

A Comparison of Three Treatments for Advanced HIV Disease in Patients Who Have Received Nucleoside Therapy in the Past

Optimizing Treatment for Treatment-Experienced, HIV-Infected People

A Study of Three Treatment Combinations Using Zidovudine Plus Lamivudine Plus Indinavir in HIV-Infected Patients

A Study of Three Anti-HIV Drug Combinations in Patients Who Have Taken Amprenavir

The Safety and Effectiveness of Zidovudine in the Treatment of Patients With Early AIDS Related Complex

A Phase I/II Study of Hyperimmune IVIG in Slowing Progression of Disease in HIV-Infected Children

Thalidomide for Treatment of Oral and Esophageal Aphthous Ulcers and HIV Viremia in Patients With HIV Infection

Antiviral Activity of and Resistance to Lamivudine in Combination With Zidovudine, Stavudine, or Didanosine

Safety of and Immune Response to the Human Papillomavirus (HPV) Vaccine in HIV-Infected Women

Virologic Responses To New Nucleoside Regimens After Prolonged ZDV or ddI Monotherapy

A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides

Effects of a Uridine Supplement on HIV Infected Adults With Lipoatrophy

Nitazoxanide Plus Ribavirin and Peginterferon for Therapy of Treatment Naive HCV Genotype 1 and HIV Coinfected Subjects

A Phase I Study of Safety and Pharmacokinetics of Nevirapine in HIV-1 Infected Pregnant Women and Neonates Born to HIV-1 Infected Mothers