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Clinical Trials in Miami | 5,521 Studies Near You | Clareo Health

Clinical Trials LocationsMiami

Clinical Trials in Miami

Discover 5,521 clinical trials near Miami, Florida. Find research studies in your area.

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Showing 3941-3960 of 5,521 trials

TERMINATEDPhase 1/2< 1 mile

A Phase I/II Trial of AEZS-108 in Urothelial Cancer Patients Who Failed Platinum-chemotherapy

NCT01234519

The purpose of this study is to determine the appropriate dose of AEZS-108 to treat patients with a tumor of the urinary system.

Urothelial Carcinoma

AEterna Zentaris12 participantsStarted Nov 2010

Miami, Florida, United States • Philadelphia, Pennsylvania, United States

COMPLETEDPhase 3< 1 mile

Safety and Efficacy Study Evaluating TRx0237 in Subjects With Mild to Moderate Alzheimer's Disease

NCT01689246

The purpose of this study is to determine the safety and efficacy of TRx0237 in the treatment of subjects with mild to moderate Alzheimer's Disease.

Alzheimer's Disease

TauRx Therapeutics Ltd891 participantsStarted Jan 2013

Phoenix, Arizona, United States • Laguna Hills, California, United States • Los Angeles, California, United States +118 more locations

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Breast Cancerin Miami Lung Cancerin Miami Prostate Cancerin Miami Colorectal Cancerin Miami Melanomain Miami Leukemiain Miami Lymphomain Miami Pancreatic Cancerin Miami Ovarian Cancerin Miami Brain Cancerin Miami Diabetesin Miami

Data from ClinicalTrials.govTerms

WITHDRAWNNA< 1 mile

Obstructive Sleep Apnea in Elective Orthopaedic Surgery

NCT03166462

Demand for Total Knee Arthroplasty (TKA) and Total Hip Arthroplasty (THA) is increasing steadily and is projected to continue trending upwards in the coming years. Concomitant with that trend is the increase in prevalence of obesity. Obesity serves as a common risk factor for osteoarthritis, obstructive sleep apnea and medical complications. Obstructive Sleep Apnea (OSA) is defined as episodes of obstructive apneas and hypopneas during sleep, with daytime somnolence. It occurs commonly in obese, middle age and elderly men and has an estimated prevalence of 5% - 9%. Pre-operative screening for elective surgical procedures is a critical component of a successful surgical outcome. Patients with medical comorbidities ideally will undergo medical treatment or optimization to minimize the risk peri-operatively and post-operatively. Obstructive sleep apnea has been shown in numerous studies to be a risk factor for cardiopulmonary complications following surgery. The contributing factors include alterations in REM sleep post-operatively and opioid induced respiratory suppression post-operatively. The STOP-BANG patient questionnaire is a validated patient survey that uses both objective and subjective data to screen patients for their risk of OSA. The sensitivity of the STOP-BANG questionnaire for moderate-to-severe OSA has been estimated as high as 97.74%. Authors have also shown that higher STOP-BANG scores are independently associated with increased risk for post-operative complication. Other authors have utilized similar pre-operative questionnaires to screen for occult pulmonary disease in patients scheduled for elective joint arthroplasty. They found a slightly increased incidence of OSA in this population as compared with the national average, over 50% of which were previously undiagnosed. The American Society of Anesthesiologists task force on perioperative management of patients with OSA published extensive guidelines aimed at reducing morbidity and mortality. Improved diagnosis pre-operatively could aid in proper compliance with these guidelines. These recommendations include preferential use of regional analgesia, reduction in systemic opioids, monitoring of oxygen saturation and nonsupine posture. The mainstay of treatment for OSA is a positive pressure airway device such as Continuous Positive Airway Pressure (CPAP) or in severe cases Nasal Intermittent Positive Pressure Ventilation (NIPPV). Post-operatively continuation of these treatments in patients with known OSA is often recommended. Some authors have demonstrated reductions in Apnea-Hypopnea Index postoperatively through the use of CPAP. However, a recent meta-analysis evaluating the effect of pre-operative or post-operative CPAP in patients with OSA concluded that the use of CPAP did not reduce post-operative adverse events. Given the projected increase in demand for joint arthroplasty, the ever-increasing incidence of obesity, the ambiguity surrounding the topic and the potential to clinically impact post-operative morbidity, mortality and health care costs, shows the need for further studies.

Sleep Apnea, ObstructiveTotal Knee ArthroplastyTotal Hip Arthroplasty

University of MiamiStarted Feb 2018

Miami, Florida, United States

COMPLETEDPhase 3< 1 mile

Idalopirdine in Patients With Mild-moderate Alzheimer's Disease Treated With Donepezil

NCT02006641

To establish efficacy of Idalopirdine as adjunctive therapy to donepezil for symptomatic treatment of patients with mild-to-moderate Alzheimer's disease (AD).

Alzheimer's Disease

H. Lundbeck A/S858 participantsStarted Feb 2014

Phoenix, Arizona, United States • Fayetteville, Arkansas, United States • Anaheim, California, United States +159 more locations

COMPLETEDPhase 3< 1 mile

Dual Action of Liraglutide and Insulin Degludec in Type 2 Diabetes: A Trial Comparing the Efficacy and Safety of Insulin Degludec/Liraglutide, Insulin Degludec and Liraglutide in Subjects With Type 2 Diabetes

NCT01336023

This trial is conducted globally. The aim of this trial is to compare the efficacy and safety of insulin degludec/liraglutide (IDegLira) versus insulin degludec (IDeg) and liraglutide (Lira) in subjects with type 2 diabetes. Subjects are to continue their pre-trial treatment with metformin or metformin + pioglitazone throughout the entire trial.

DiabetesDiabetes Mellitus, Type 2

Novo Nordisk A/S1,663 participantsStarted May 2011

Birmingham, Alabama, United States • Anaheim, California, United States • Bermuda Dunes, California, United States +299 more locations

COMPLETEDPhase 1/24.3 miles

A Study of Ixazomib Administered in Combination With Lenalidomide and Low-Dose Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma

NCT01217957

The purpose of Phase 1 of this study was to determine the safety, tolerability, maximum tolerated dose (MTD), and recommended Phase 2 dose (RP2D) of oral ixazomib administered in combination with lenalidomide and low-dose dexamethasone in participants with newly diagnosed multiple myeloma (NDMM). The purpose of Phase 2 of this study was to determine the overall response rate (ORR) and further evaluate the tolerability and toxicity of the combination of oral ixazomib, lenalidomide, and low-dose dexamethasone in patients with NDMM.

Multiple Myeloma

Millennium Pharmaceuticals, Inc.65 participantsStarted Nov 2010

Scottsdale, Arizona, United States • Los Angeles, California, United States • Denver, Colorado, United States +13 more locations

COMPLETEDPhase 17.3 miles

A Study to Evaluate the Safety and Immunogenicity of MEDI7510 in Older Adults

NCT02289820

The goal of this study is to evaluate the safety, tolerability and immunogenicity of ascending doses of adjuvant in combination with a single dosage level of RSV sF in adults 60 years or older who are healthy or who have stable, chronic underlying medical conditions. This study will also provide preliminary safety and immunogenicity data to support concurrent dosing of MEDI7510 with influenza vaccine (IIV), and to assess the safety of MEDI7510 at a dose previously assessed in the Phase 1a study.

Respiratory Syncytial Virus (RSV)

MedImmune LLC363 participantsStarted Jan 2015

Orlando, Florida, United States • South Miami, Florida, United States • Kansas City, Missouri, United States +2 more locations

COMPLETEDPhase 37.3 miles

Compare Two Dosing Algorithms in Insulin-Naive Patients With Type 2 Diabetes Mellitus

NCT00391209

This randomized, multicenter, open-label, active-comparator, 2-arm, parallel-group, 6 month study with approximately 360 patients will compare the efficacy of two treatment regimens (Algorithm A versus Algorithm B) in insulin-naive patients with type 2 diabetes not optimally controlled by one or more oral antihyperglycemic medications. Patients will be assigned randomly to receive one of the following treatment groups: Algorithm A is defined as a simplified diabetes management regimen starting with a fixed dose of HIIP (also known as AIR® Inhaled Insulin)(AIR® is a registered trademark of Alkermes,Inc.), titrating 2 times per week based on 2 times per week 4 point blood glucose values for the first month and titrating 1 time per week based on once weekly 4-point blood glucose values for the remainder of the study, increasing total daily dose by a maximum of 6 U per day. Algorithm B is defined as an intensive diabetes management regimen, starting with an adjusted dose of AIR® Inhaled Insulin, titrating 2 times per week based on daily 4 point blood glucose values, with sustained monitoring of dose and blood glucose throughout the study, increasing total daily dose by a maximum of 8 U per day.

Diabetes Mellitus, Type 2

Eli Lilly and Company379 participantsStarted Oct 2006

Santa Ana, California, United States • Washington D.C., District of Columbia, United States • Hollywood, Florida, United States +39 more locations

COMPLETEDPhase 38.9 miles

Treatment Seeking Participants With Opioid Use Disorders Assessing Tolerability of Depot Injections of Buprenorphine

NCT02357901

This is a randomized, double-blind, placebo controlled, multicenter study in male and female participants who are seeking treatment for opioid use disorder.

Opioid DependenceOpioid Related Disorders

Indivior Inc.665 participantsStarted Jan 2015

Haleyville, Alabama, United States • Hamilton, Alabama, United States • Little Rock, Arkansas, United States +35 more locations

COMPLETEDPhase 411 miles

SISTERS: Spasticity In Stroke Study - Randomized Study

NCT01032239

To demonstrate that Intrathecal Baclofen (ITB) Therapy, compared to Best Medical Treatment (BMT), has superior efficacy in the treatment of severe spasticity in adult post-stroke patients with generalized spastic hypertonia who have not reached their therapy goal with other treatment interventions assessed by a decrease in the average Ashworth Scale (AS) score in the lower extremities.

Severe Spasticity

MedtronicNeuro61 participantsStarted Nov 2009

Irvine, California, United States • Washington D.C., District of Columbia, United States • Doral, Florida, United States +22 more locations

COMPLETEDPhase 125 miles

Long-term Follow-up of Participants From Studies Evaluating GSK HIV Vaccine

NCT01092611

The purpose of this long-term follow-up study is to assess the long-term health status of HIV-infected subjects who previously participated in GSK-sponsored trials evaluating the investigational HIV vaccine 732462. This study will provide additional data concerning the long-term benefits/risks associated with vaccination. No vaccine will be administered during the study period. Vaccines were administered during the primary studies.

GlaxoSmithKline190 participantsStarted Mar 2010

Bakersfield, California, United States • Fort Lauderdale, Florida, United States • Orlando, Florida, United States +38 more locations

COMPLETEDPhase 1/2606 miles

Study Evaluating Inotuzumab Ozogamicin [CMC-544] Administered In Combination With Rituximab In Subjects With Non-Hodgkin's Lymphoma (NHL)

NCT00299494

The purpose of the study is to determine the tolerability, the initial safety profile and maximum tolerated dose, and to obtain preliminary information on the antitumor activity of inotuzumab ozogamicin \[CMC-544\] in combination with rituximab in subjects with follicular, diffuse large B-Cell, or mantle cell NHL.

B-Cell Lymphoma

Pfizer119 participantsStarted May 2006

Birmingham, Alabama, United States • Birmingham, Alabama, United States • Birmingham, Alabama, United States +35 more locations

COMPLETEDPhase 2667 miles

A Randomized Placebo-Controlled Study of Lovastatin in Children With Neurofibromatosis Type 1

NCT00853580

The specific aim of this study is to determine whether Lovastatin ™ significantly improves visual spatial learning and/or sustained attention in children with NF1. Secondary Aims: To evaluate the effect of Lovastatin ™ on measures of executive function, behavior and quality of life in children with NF1 and cognitive deficits. To further evaluate the toxicity and tolerability of Lovastatin ™ in children with NF1 and cognitive deficits. Hypotheses It is hypothesized that Lovastatin ™ will improve the visual spatial memory and/or attention deficits in children with NF1. This is based on studies demonstrating that Lovastatin ™ has significantly improved impairments in visual spatial memory and attention in the NF1 murine model. It is further expected that Lovastatin ™ will be safe and well tolerated over a 16-week period.

Neurofibromatosis Type 1

University of Alabama at Birmingham146 participantsStarted Jul 2009

Birmingham, Alabama, United States • Los Angeles, California, United States • Washington D.C., District of Columbia, United States +9 more locations

COMPLETED684 miles

Third International Study on Mechanical Ventilation

NCT01093482

The objective of this study is to obtain a better understanding of the spectrum of use of mechanical ventilation in intensive care units: 1. Main analysis: To know the all-cause mortality rate in mechanically ventilated patients 2. Secondary analyses: * To know the current status of mechanical ventilation in the intensive care unit and determine the number and percentage of patients who are admitted to an intensive care unit and require mechanical ventilation. * To compare the results with prior data collected in previous observational studies (1998 and 2004) * Non-invasive positive pressure ventilation * Weaning * Use of adjuvant therapies as steroids or selective digestive decontamination * Sedation including prevalence of delirium in mechanically ventilated patients * Prediction of the duration of mechanical ventilation * Other

Acute Respiratory Failure

Hospital Universitario Getafe8,151 participantsStarted Apr 2010

Iowa City, Iowa, United States • Louisville, Kentucky, United States • Boston, Massachusetts, United States +474 more locations

COMPLETEDPhase 1800 miles

PK and PD Study of Oral F/TAF for HIV Prevention

NCT02904369

This multi-center Phase I study is designed to characterize the PK and PD of F/TAF oral tablets to assess systemic and genital tract bioavailability in healthy women. The oral tablets to be used in the study are F/TAF (200/10 mg), F/TAF (200/25 mg) and F/TDF (200/300 mg, Truvada). Samples will be obtained before, during and after dosing in two study phases.

CONRAD73 participantsStarted Oct 2016

Pittsburgh, Pennsylvania, United States • Norfolk, Virginia, United States • Santo Domingo, Dominican Republic

COMPLETEDNA967 miles

ICU Triage Practices in a Cancer Hospital

NCT03401411

The primary objective of this study is aimed at analyzing the ICU triage practices of clinicians at a cancer hospital with and without the use of an algorithm-based triage tool, and to assess whether or not the triage tool improves the consensus amongst practioners on the prioritization of patients for ICU admission. Secondary objectives include assessment of whether or not triage practices based on guidelines correlate with what is done in actual practice.

Intensive Care UnitsTriage

M.D. Anderson Cancer Center257 participantsStarted Nov 2014

Houston, Texas, United States • Houston, Texas, United States • Manta, Manabí Province, Ecuador

COMPLETEDPhase 31012 miles

Evaluate the Efficacy and Safety of Insulin Compared to Glargine in Patients With Type 2 Diabetes

NCT00437112

A study to compare Human Inhalation Powder (also known as AIR® Inhaled Insulin) (AIR® is a registered trademark of Alkermes, Inc.)with insulin glargine injections in patients with Type 2 diabetes who are currently taking oral medications and have not previously taken insulin. Change in HbA1c levels will be reviewed to determine superiority or inferiority of the AIR Inhaled Insulin regimen.

Diabetes Mellitus, Type 2

Eli Lilly and Company142 participantsStarted Feb 2007

Greenbrae, California, United States • Topeka, Kansas, United States • Toms River, New Jersey, United States +16 more locations

COMPLETEDPhase 31023 miles

A Safety and Efficacy Study of AEGR-733 to Treat Homozygous Familial Hypercholesterolemia (FH)

NCT00730236

The goal of this trial is to study the effects of AEGR-733 on LDL cholesterol, other lipids as well as measures of safety over the long-term.

Homozygous Familial Hypercholesterolemia

Aegerion Pharmaceuticals, Inc.29 participantsStarted Dec 2007

Los Angeles, California, United States • Philadelphia, Pennsylvania, United States • London, Ontario, Canada +7 more locations

COMPLETEDPhase 21100 miles

Pharmacokinetic, Efficacy, and Safety Study of Octafibrin Compared to Haemocomplettan/Riastap

NCT01575756

The purpose of this study is to investigate pharmacokinetic properties, surrogate efficacy and safety of Octafibrin compared to Haemocomplettan® P/RiaSTAPTM in patients with congenital fibrinogen deficiency

Congenital Fibrinogen DeficiencyAfibrinogenemia

Octapharma22 participantsStarted Jun 2013

Aurora, Colorado, United States • New Hyde Park, New York, United States • Sofia, Bulgaria +7 more locations

COMPLETEDPhase 31154 miles

Can Valacyclovir Delay the Need for Initiation of Human Immunodeficiency Virus (HIV) Treatment in HIV-infected Individuals?

NCT00860977

This study is a multicentre, randomized, placebo-controlled, fully blinded, clinical trial of twice daily oral valacyclovir 500mg versus placebo with the goal of delaying the need for initiating HAART among HIV infected individuals who neither use nor require HAART, and who have not used chronic suppressive anti-HSV therapy for at least the 6 months prior to study initiation.

HIV InfectionHerpes Simplex Type IIHIV Infections

University Health Network, Toronto202 participantsStarted Mar 2010

Buenos Aires, Argentina • Rio de Janeiro, Brazil • São Paulo, Brazil +22 more locations

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