Clinical Trials in Massachusetts

Showing 6941-6960 of 17,868 trials

The Effect of De-Prescribing Antipsychotics on Health and Quality of Life for People With Dementia

NCT05172687

This study aims to analyze how warning letters sent to physicians prescribing high levels of the antipsychotic quetiapine affected the health and quality of life of their patients with dementia. Using a randomized controlled trial conducted by the Centers for Medicare and Medicaid Services (CMS) in 2015, this secondary study looks at the effects of potential de-prescribing of antipsychotics by study physicians induced by the letters. The central question is whether the intervention led to better health and quality of life outcomes by encouraging more guideline-concordant care and whether changes in physicians' prescription behavior caused unintended harms.

Alzheimer DiseaseDementiaPrescribing, Off-Label

Columbia University336,460 participantsStarted Apr 2015

Boston, Massachusetts, United States • Cambridge, Massachusetts, United States • New York, New York, United States

COMPLETEDPhase 126 miles

A Study to Assess Safety and Tolerability of CC-486 (ONUREG®, Oral Azacitidine) in Combination Therapy in Participants With Acute Myeloid Leukemia (AML)

NCT04887857

The purpose of this study is to evaluate the safety, tolerability, and preliminary efficacy of CC-486 (ONUREG®) in combination with venetoclax in relapsed and/or refractory Acute Myeloid Leukemia (AML) and newly diagnosed AML.

Leukemia, Myeloid, Acute

Celgene6 participantsStarted Dec 2021

Stanford, California, United States • Denver, Colorado, United States • Boston, Massachusetts, United States +7 more locations

The Effect of De-Prescribing Antipsychotics on Health and Quality of Life for People With Dementia

A Study to Assess Safety and Tolerability of CC-486 (ONUREG®, Oral Azacitidine) in Combination Therapy in Participants With Acute Myeloid Leukemia (AML)

Find Trials by Condition in Massachusetts

A Study of ABBV-011 Alone and in Combination With Budigalimab (ABBV-181) in Participants With Relapsed or Refractory Small Cell Lung Cancer

PF-07304814 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)

Weight Loss and Physical Activity Lifestyle Interventions In Post Liver And Kidney Transplants

Interstage Monitoring Using an Implantable Loop Recorder: A Pilot Study

Study in Pediatric Subjects With Peanut Allergy to Evaluate Efficacy and Safety of Dupilumab as Adjunct to AR101 (Peanut Oral Immunotherapy)

Practice of Acceptance, Awareness, and Compassion in Caregiving (PAACC)

Behavioral Economic Analysis of Demand for Marijuana

Fractionated Gemtuzumab Ozogamicin Followed by Non-engraftment Donor Leukocyte Infusions for Relapsed/Refractory Acute Myeloid Leukemia

Actuate 1901: 9-ING-41 in Myelofibrosis

Omnibond vs Dermabond

Capsaicin Cream as an Adjunctive Therapy for Nausea and Vomiting of Pregnancy

The Study Evaluating the Efficacy and Safety of OK-101 in Subjects With Dry Eye Disease

Long-term Safety and Efficacy of GSK3196165 (Otilimab) in the Treatment of Rheumatoid Arthritis (RA)

A Study of AL101 Monotherapy in Patients With Notch Activated Triple Negative Breast Cancer

Study Comparing Stereotactic Body Radiotherapy vs Conventional Palliative Radiotherapy (CRT) for Spinal Metastases

Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor

Lung EpiCheck Biomarkers Development Study

Study to Evaluate the Pharmacokinetics, Safety, and Pharmacodynamics of INCB054707 in Participants With Normal and Impaired Renal Function and Participants on Hemodialysis