Clinical Trials in Maryland

Showing 7961-7980 of 17,687 trials

Combined Intrathecal and Intravenous VTS-270 Therapy for Liver and Neurological Disease Associated With Niemann-Pick Disease, Type C1

NCT03887533

Background: For people who have Niemann-Pick disease, type C1 (NPC1), cholesterol and other fats have trouble moving out of liver and other tissue cells. This makes the cells sick. Researchers want to find out if a drug called VTS-270 can help. Objective: To test if VTS-270 is safe and effective in treating chronic liver disease associated with NPC1. Eligibility: People ages 3-60 with NPC1 Design: Participants may be screened by phone or under another protocol. Participants will have visits once a month for 12 months. If they have intrathecal injections, the study may last 15 months or more. The first visit will last about 5 days. Others will last 2-3 days. Participants will get VTS-270 injected into a vein at each visit. They can also choose to have intrathecal injections. These are like spinal taps. Some visits will also include: Physical exam Urine tests Blood tests. A small tube or needle will be inserted into the participants vein to collect blood. The small tube will also be used to give the VTS-270. Hearing tests: For one test, participants will have electrodes taped to their head. These will record brain waves. Breathing tests Ultrasound of abdomen: Sounds waves will take pictures of the participant s body. Chest x-ray: This is a picture of the lungs.

Niemann-Pick Disease, Type C1

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)2 participantsStarted Jan 2020

Bethesda, Maryland, United States

UNKNOWN17 miles

Cortical Excitability in Post-traumatic Epilepsy

NCT05517954

To test whether measures of cortical excitability derived from motor cortex transcranial magnetic stimulation (TMS) in patients with traumatic brain injury reflect heightened excitability relative to healthy controls and whether such measures can be used to distinguish patients with post-traumatic epilepsy from patients with head trauma but no epilepsy

Traumatic Brain InjuryCortical ExcitabilityEpilepsy

Mid-Atlantic Epilepsy and Sleep Center, LLC30 participantsStarted Aug 2022

Bethesda, Maryland, United States

Combined Intrathecal and Intravenous VTS-270 Therapy for Liver and Neurological Disease Associated With Niemann-Pick Disease, Type C1

Cortical Excitability in Post-traumatic Epilepsy

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Human Samples and Data Repository

ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma

A Study to Investigate Intravenous Tocilizumab in Participants With Moderate to Severe COVID-19 Pneumonia

Frameshift Peptides of Children With NF1

Concussion Active Rehabilitation

Efficacy and Safety of a New Dilution and Injection Volume of AbobotulinumtoxinA for the Treatment of Glabellar Lines

A Prospective Study of Early Mechanical Stabilization and Bleeding in Disruption of the Pelvic Ring

Safety and Efficacy of AbobotulinumtoxinA for the Treatment of Platysmal Bands

Phase 2 Study on Effects of Obeticholic Acid (OCA) on Lipoprotein Metabolism in Participants With Primary Biliary Cirrhosis

Evaluation of the Use of Medical Scribes in VAMC Emergency Departments and Specialty Care Clinics

Post Approval Study: NOVATION Ceramic Articulation Hip System

The Safety, Efficacy and Pharmacokinetics of ARQ-151 Cream in Subjects With Chronic Plaque Psoriasis

A Trial of LY3056480 in Patients With SNLH

Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis Sicca

Clobetasol Propionate Spray Versus Vehicle Spray for the Management of Moderate to Severe Plaque Psoriasis of the Scalp

Lenalidomide Monotherapy in R/R DLBCL

Study to Evaluate the Safety and Efficacy of SDP-4 in Subjects With Dry Eye Disease (DED)

Dose Escalation of RMC-4630 Monotherapy in Relapsed/Refractory Solid Tumors