Clinical Trials in Los Angeles

Showing 741-760 of 16,901 trials

Glofitamab With Pirtobrutinib for Relapsed or Refractory Mantle Cell Lymphoma

NCT06252675

This phase II trial tests the safety and effectiveness of glofitamab given in combination with pirtobrutinib in treating patients with mantle cell lymphoma that has come back after a period of improvement (relapsed) or that has not responded to previous treatment (refractory). Glofitamab and obinutuzumab are monoclonal antibodies that may interfere with the ability of cancer cells to grow and spread. Obinutuzumab may also reduce the risk of immune-related conditions from treatment. Pirtobrutinib is in a class of medications called kinase inhibitors. It works by blocking the action of the protein that signals cancer cells to multiply. Giving glofitamab in combination with pirtobrutinib may be safe, tolerable and/or effective in treating patients with relapsed or refractory mantle cell lymphoma.

Mantle Cell Lymphoma

University of California, San Francisco30 participantsStarted Jun 2024

Davis, California, United States • Los Angeles, California, United States • San Francisco, California, United States

COMPLETED< 1 mile

Improving the Diagnosis of Common Variable Immune Deficiency

NCT03335605

This is an observational, case-control study with a single blood draw among two cohorts, patients with antibody deficiency (e.g., CVID) and healthy controls. Samples will be analyzed by mass cytometry (CyTOF) to examine the major signaling pathways of all circulating innate and adaptive immune cell types, as well as whole exome sequencing. The goal is to improve our general understanding of the human immune response to infections and the diagnosis of CVID.

CVI - Common Variable Immunodeficiency

University of California, Los Angeles24 participantsStarted May 2019

Los Angeles, California, United States

Glofitamab With Pirtobrutinib for Relapsed or Refractory Mantle Cell Lymphoma

Improving the Diagnosis of Common Variable Immune Deficiency

Find Trials by Condition in Los Angeles

A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use

A Study of PF-08046049/SGN-BB228 in Advanced Melanoma and Other Solid Tumors

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

A Study of LY4584180 in Adult Participants With Previously Treated Blood Cancers

Pivotal 2 Study of RGX-314 Gene Therapy in Participants With nAMD

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

A Study to Evaluate the Long-Term Efficacy and Safety of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 3)

This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

A Clinical Study of Tulisokibart (MK-7240) to Treat Radiographic Axial Spondyloarthritis (MK-7240-013)

Comparison of Uncomplicated Candidemia Therapy Duration in Children

Tapinarof for the Treatment of Plaque Psoriasis in Pediatric Subjects

A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain

A Study to Investigate the Safety and Biodistribution of a Single Intrathecal (IT) Injection of INS1201 in Ambulatory Males With Duchenne Muscular Dystrophy (DMD)

Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia

Surgery in Treating Patients With Early Stage Anal Canal or Perianal Cancer and HIV Infection

First-in-Human Study of DS-3939a in Participants With Advanced Solid Tumors

A Phase 1 of CTX-8371 in Patients With Advanced Malignancies