Clinical Trials in Los Angeles

Showing 7341-7360 of 12,794 trials

Topical Rapamycin to Erase Angiofibromas in TSC

NCT01526356

The study is a multi-center prospective, randomized, double-blind, placebo-controlled evaluation of the safety and efficacy of a topically applied formulation of rapamycin to cutaneous angiofibromas in subjects with Tuberous Sclerosis Complex (TSC). Subjects will apply either the topical vehicle containing rapamycin or the topical vehicle alone nightly to their angiofibromas for six months. The primary goal of this study is to evaluate the efficacy of the topical medication for reduction of cutaneous angiofibromas in patients with TSC. The secondary goal of this study is to confirm the safety of the topical medication.

AngiofibromasTuberous Sclerosis

The University of Texas Health Science Center, Houston179 participantsStarted May 2012

Birmingham, Alabama, United States • Los Angeles, California, United States • Oakland, California, United States +7 more locations

COMPLETEDPhase 2< 1 mile

Lung-MAP: Taselisib as Therapy in Treating Patients With Stage IV Squamous Cell Lung Cancer and Positive Biomarker Matches

NCT02785913

This phase II trial studies how well taselisib (GDC-0032) works in treating patients with stage IV squamous cell lung cancer that has come back after previous treatment. This is a sub-study that includes all screened patients positive for the phosphoinositide 3-kinase (PI3K) biomarker. PI3K can cause tumor cells to grow more quickly. Taselisib may decrease the activity of PI3K and may be able to shrink tumors.

Recurrent Squamous Cell Lung CarcinomaStage IV Squamous Cell Lung Carcinoma

SWOG Cancer Research Network31 participantsStarted Nov 2014

Birmingham, Alabama, United States • Anchorage, Alaska, United States • Anchorage, Alaska, United States +1108 more locations

Topical Rapamycin to Erase Angiofibromas in TSC

Lung-MAP: Taselisib as Therapy in Treating Patients With Stage IV Squamous Cell Lung Cancer and Positive Biomarker Matches

Find Trials by Condition in Los Angeles

Radiation Therapy Plus Chemotherapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum

Evaluation of Memory Skills in Patients Receiving Radiation Therapy for Brain Metastases

A Bioequivalence Study With Clinical Endpoints to Evaluate the Safety and Therapeutic Equivalence of Permethrin Cream 5% & Elimite™ in Subjects With Scabies

Study of Oliceridine (TRV130) for the Treatment of Moderate to Severe Acute Pain After Abdominoplasty

Study of Intravitreal REGN2176-3 in Participants With Neovascular ("Wet") Age-Related Macular Degeneration (AMD)

Safety and Efficacy of OT-82 in Participants With Relapsed or Refractory Lymphoma

A Safety and Efficacy Trial of Inhaled Mannitol in Adult Cystic Fibrosis Subjects

A Study to Assess Safety and Efficacy of KarXT in Adult Patients With Schizophrenia

The Dystonia Coalition Natural History and Biospecimen Repository for Isolated Dystonias

A Study of Pertuzumab in Combination With Trastuzumab Plus an Aromatase Inhibitor in Participants With Metastatic Human Epidermal Growth Factor Receptor 2 (HER2)-Positive and Hormone Receptor-Positive Advanced Breast Cancer

Comparative Study of Two Marketed Spherical Soft Contact Lenses

Hormone Therapy Plus Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Prostate Cancer

Radiation Therapy in Treating Patients With Stage II or Stage III Oropharyngeal Cancer

Temozolomide Plus Radiation Therapy in Treating Patients With Newly Diagnosed Anaplastic Oligodendrogliomas or Mixed Anaplastic Oligoastrocytomas

Danirixin Dose Ranging Study in Participants With Chronic Obstructive Pulmonary Disease (COPD)

Cholinesterase Inhibitor Discontinuation

Sebacia Postmarket Study of Real-World Use

An Evidence Based Delivery Model of Care for Newly Implanted Adult CI Recipients